Synthesis and characterization of silver(I) complexes bearing phenanthroline derivatives as ligands: Cytotoxicity and DNA interaction evaluation

Rocha, Josias S.; Pereira, George B.S.; Oliveira, Gabriela P.; Lima, Mauro A.; Araujo-Neto, João H.; Pinto, Luciano S.; Forim, Moacir R.; Zanetti, Renan D. [UNESP]; Netto, Adelino V.G. [UNESP]; Castellano, Eduardo E.; Rocha, Fillipe V.

Synthesis and characterization of silver(I) complexes bearing phenanthroline derivatives as ligands: Cytotoxicity and DNA interaction evaluation

In this work, three new silver(I) complexes, [Ag(NO2-NN)(tu)]NO3 (1), [Ag(NON-NN)(tu)]NO3 (2), and [Ag(CN-NN)(tu)]NO3 (3) and (R-N'N”= extended phenanthroline ligand with aromatic diamines replaced with R = NO2; NON (furazan); CN (nitrile); tu = thiourea) were synthesized and fully characterize...

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Autores:	Rocha, Josias S., Pereira, George B.S., Oliveira, Gabriela P., Lima, Mauro A., Araujo-Neto, João H., Pinto, Luciano S., Forim, Moacir R., Zanetti, Renan D. [UNESP], Netto, Adelino V.G. [UNESP], Castellano, Eduardo E., Rocha, Fillipe V.
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2021
País:	Brasil
Institución:	Universidade Estadual Paulista (UNESP)
Repositorio:	Repositório Institucional da UNESP
Idioma:	inglés
OAI Identifier:	oai:repositorio.unesp.br:11449/229049
Acceso en línea:	http://dx.doi.org/10.1016/j.inoche.2021.108757 http://hdl.handle.net/11449/229049
Access Level:	acceso abierto
Palabra clave:	Complexes of silver(I) Cytotoxicity DNA interactions Phenanthroline derivatives

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spelling	Synthesis and characterization of silver(I) complexes bearing phenanthroline derivatives as ligands: Cytotoxicity and DNA interaction evaluationComplexes of silver(I)CytotoxicityDNA interactionsPhenanthroline derivativesIn this work, three new silver(I) complexes, [Ag(NO2-NN)(tu)]NO3 (1), [Ag(NON-NN)(tu)]NO3 (2), and [Ag(CN-NN)(tu)]NO3 (3) and (R-N'N”= extended phenanthroline ligand with aromatic diamines replaced with R = NO2; NON (furazan); CN (nitrile); tu = thiourea) were synthesized and fully characterized by the techniques of UV–Vis spectroscopy; Infrared spectroscopy; 1H and 13C{1H} NMR; molar conductivity; elemental analysis (CHN); high-resolution electrospray ionization mass spectrometry (HRMS-ESI); and X-ray diffraction (compound 3). The compounds showed themselves to be stable to light, air, and the DMSO solution. The DNA interaction assays indicated that compounds 2 and 3 interacted with the DNA, by interaction via the minor groove. Compounds 2 and 3 showed outstanding cytotoxicity towards the human cell lines A2780cis (cisplatin-resistant ovarian carcinoma), the DU-145 (prostate cancer) cells, and MRC-5 (human lung fibroblasts). The IC50 (concentration of a compound that is required for 50% inhibition of the cell viability, in vitro) values substantially overcome that of cisplatin. This data has suggested that such a molecular design is promising to develop silver(I) complexes, with high anticancer activities.Departamento de Química Univ. Federal de São CarlosUNESP – Univ. Estadual Paulista Instituto de Química Departamento de Química Analítica Físico-Química e InorgânicaInstituto de Física de São Carlos Universidade de São Paulo Avenida Trabalhador São-Carlense 400UNESP – Univ. Estadual Paulista Instituto de Química Departamento de Química Analítica Físico-Química e InorgânicaUniversidade Federal de São Carlos (UFSCar)Universidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)2022-04-29T08:30:07Z2022-04-29T08:30:07Z2021-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.inoche.2021.108757Inorganic Chemistry Communications, v. 131.1387-7003http://hdl.handle.net/11449/22904910.1016/j.inoche.2021.1087572-s2.0-85108795735Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInorganic Chemistry Communicationsinfo:eu-repo/semantics/openAccessRocha, Josias S.Pereira, George B.S.Oliveira, Gabriela P.Lima, Mauro A.Araujo-Neto, João H.Pinto, Luciano S.Forim, Moacir R.Zanetti, Renan D. [UNESP]Netto, Adelino V.G. [UNESP]Castellano, Eduardo E.Rocha, Fillipe V.2025-05-28T05:27:52Zoai:repositorio.unesp.br:11449/229049Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-05-28T05:27:52Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv	Synthesis and characterization of silver(I) complexes bearing phenanthroline derivatives as ligands: Cytotoxicity and DNA interaction evaluation
title	Synthesis and characterization of silver(I) complexes bearing phenanthroline derivatives as ligands: Cytotoxicity and DNA interaction evaluation
spellingShingle	Synthesis and characterization of silver(I) complexes bearing phenanthroline derivatives as ligands: Cytotoxicity and DNA interaction evaluation Rocha, Josias S. Complexes of silver(I) Cytotoxicity DNA interactions Phenanthroline derivatives
title_short	Synthesis and characterization of silver(I) complexes bearing phenanthroline derivatives as ligands: Cytotoxicity and DNA interaction evaluation
title_full	Synthesis and characterization of silver(I) complexes bearing phenanthroline derivatives as ligands: Cytotoxicity and DNA interaction evaluation
title_fullStr	Synthesis and characterization of silver(I) complexes bearing phenanthroline derivatives as ligands: Cytotoxicity and DNA interaction evaluation
title_full_unstemmed	Synthesis and characterization of silver(I) complexes bearing phenanthroline derivatives as ligands: Cytotoxicity and DNA interaction evaluation
title_sort	Synthesis and characterization of silver(I) complexes bearing phenanthroline derivatives as ligands: Cytotoxicity and DNA interaction evaluation
dc.creator.none.fl_str_mv	Rocha, Josias S. Pereira, George B.S. Oliveira, Gabriela P. Lima, Mauro A. Araujo-Neto, João H. Pinto, Luciano S. Forim, Moacir R. Zanetti, Renan D. [UNESP] Netto, Adelino V.G. [UNESP] Castellano, Eduardo E. Rocha, Fillipe V.
author	Rocha, Josias S.
author_facet	Rocha, Josias S. Pereira, George B.S. Oliveira, Gabriela P. Lima, Mauro A. Araujo-Neto, João H. Pinto, Luciano S. Forim, Moacir R. Zanetti, Renan D. [UNESP] Netto, Adelino V.G. [UNESP] Castellano, Eduardo E. Rocha, Fillipe V.
author_role	author
author2	Pereira, George B.S. Oliveira, Gabriela P. Lima, Mauro A. Araujo-Neto, João H. Pinto, Luciano S. Forim, Moacir R. Zanetti, Renan D. [UNESP] Netto, Adelino V.G. [UNESP] Castellano, Eduardo E. Rocha, Fillipe V.
author2_role	author author author author author author author author author author
dc.contributor.none.fl_str_mv	Universidade Federal de São Carlos (UFSCar) Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP)
dc.subject.por.fl_str_mv	Complexes of silver(I) Cytotoxicity DNA interactions Phenanthroline derivatives
topic	Complexes of silver(I) Cytotoxicity DNA interactions Phenanthroline derivatives
description	In this work, three new silver(I) complexes, [Ag(NO2-NN)(tu)]NO3 (1), [Ag(NON-NN)(tu)]NO3 (2), and [Ag(CN-NN)(tu)]NO3 (3) and (R-N'N”= extended phenanthroline ligand with aromatic diamines replaced with R = NO2; NON (furazan); CN (nitrile); tu = thiourea) were synthesized and fully characterized by the techniques of UV–Vis spectroscopy; Infrared spectroscopy; 1H and 13C{1H} NMR; molar conductivity; elemental analysis (CHN); high-resolution electrospray ionization mass spectrometry (HRMS-ESI); and X-ray diffraction (compound 3). The compounds showed themselves to be stable to light, air, and the DMSO solution. The DNA interaction assays indicated that compounds 2 and 3 interacted with the DNA, by interaction via the minor groove. Compounds 2 and 3 showed outstanding cytotoxicity towards the human cell lines A2780cis (cisplatin-resistant ovarian carcinoma), the DU-145 (prostate cancer) cells, and MRC-5 (human lung fibroblasts). The IC50 (concentration of a compound that is required for 50% inhibition of the cell viability, in vitro) values substantially overcome that of cisplatin. This data has suggested that such a molecular design is promising to develop silver(I) complexes, with high anticancer activities.
publishDate	2021
dc.date.none.fl_str_mv	2021-09-01 2022-04-29T08:30:07Z 2022-04-29T08:30:07Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.uri.fl_str_mv	http://dx.doi.org/10.1016/j.inoche.2021.108757 Inorganic Chemistry Communications, v. 131. 1387-7003 http://hdl.handle.net/11449/229049 10.1016/j.inoche.2021.108757 2-s2.0-85108795735
url	http://dx.doi.org/10.1016/j.inoche.2021.108757 http://hdl.handle.net/11449/229049
identifier_str_mv	Inorganic Chemistry Communications, v. 131. 1387-7003 10.1016/j.inoche.2021.108757 2-s2.0-85108795735
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	Inorganic Chemistry Communications
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.source.none.fl_str_mv	Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP
instname_str	Universidade Estadual Paulista (UNESP)
instacron_str	UNESP
institution	UNESP
reponame_str	Repositório Institucional da UNESP
collection	Repositório Institucional da UNESP
repository.name.fl_str_mv	Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv	repositoriounesp@unesp.br
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score	15.300724

Synthesis and characterization of silver(I) complexes bearing phenanthroline derivatives as ligands: Cytotoxicity and DNA interaction evaluation

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