Error in pharmaceutical compounding of alprazolam capsules

The increase of pharmaceutical drugs formulations consumption by Brazilian population demanded a greater action from the official laboratory to verify the conformity of these products, as the majority of them are composed by anxiolytics. This study reports a serious manipulation error in preparing a...

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Bibliographic Details
Authors: Trujillo, Luz Marina, Batistic-Longatto, Mônica A., Zorzetto, Maria Ângela P., Franciosi, Sueli O.
Format: article
Status:Published version
Publication Date:2007
Country:Brasil
Institution:Instituto Adolfo Lutz
Repository:Revista do Instituto Adolfo Lutz (Online)
Language:Portuguese
OAI Identifier:oai:ojs.periodicos.saude.sp.gov.br:article/32812
Online Access:https://periodicos.saude.sp.gov.br/RIAL/article/view/32812
Access Level:Open access
Keyword:alprazolam
benzodiazepine
pharmaceutical compounded preparation
benzodiazepina
medicamento manipulado
Description
Summary:The increase of pharmaceutical drugs formulations consumption by Brazilian population demanded a greater action from the official laboratory to verify the conformity of these products, as the majority of them are composed by anxiolytics. This study reports a serious manipulation error in preparing alprazolam capsules formulation, where the chlordiazepoxide was placed instead of alprazolam, being both drugs belonged to therapeutic class of the benzodiazepines. A warning on the importance of manipulation process control of drugs is presented.