Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery

Anthocyanins obtained from jambolan have been used as active agents in different carboxymethyl starch-based tablet formulations and their release profiles evaluated in simulated gastric fluids (SGF) and simulated intestinal (SIF) fluids. Structural analysis highlighted a strong interaction between a...

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Detalles Bibliográficos
Autores: Sabino, Luiz Bruno de Sousa, Copes, Francesco, Saulais, Solène, Brito, Edy Sousa de, Silva Júnior, Ivanildo José da, Le, Tien Canh, Mateescu, Mircea Alexandru, Mantovani, Diego
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:Brasil
Institución:Universidade Federal do Ceará (UFC)
Repositorio:Repositório Institucional da Universidade Federal do Ceará (UFC)
Idioma:inglés
OAI Identifier:oai:repositorio.ufc.br:riufc/69546
Acceso en línea:http://www.repositorio.ufc.br/handle/riufc/69546
Access Level:acceso abierto
Palabra clave:Anthocyanins
Carboxymethyl starch
Bioactive agent delivery
Monolithic tablets
Syzygium cumini
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dc.title.pt_BR.fl_str_mv Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery
title Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery
spellingShingle Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery
Sabino, Luiz Bruno de Sousa
Anthocyanins
Carboxymethyl starch
Bioactive agent delivery
Monolithic tablets
Syzygium cumini
title_short Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery
title_full Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery
title_fullStr Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery
title_full_unstemmed Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery
title_sort Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery
dc.creator.none.fl_str_mv Sabino, Luiz Bruno de Sousa
Copes, Francesco
Saulais, Solène
Brito, Edy Sousa de
Silva Júnior, Ivanildo José da
Le, Tien Canh
Mateescu, Mircea Alexandru
Mantovani, Diego
author Sabino, Luiz Bruno de Sousa
author_facet Sabino, Luiz Bruno de Sousa
Copes, Francesco
Saulais, Solène
Brito, Edy Sousa de
Silva Júnior, Ivanildo José da
Le, Tien Canh
Mateescu, Mircea Alexandru
Mantovani, Diego
author_role author
author2 Copes, Francesco
Saulais, Solène
Brito, Edy Sousa de
Silva Júnior, Ivanildo José da
Le, Tien Canh
Mateescu, Mircea Alexandru
Mantovani, Diego
author2_role author
author
author
author
author
author
author
dc.subject.por.fl_str_mv Anthocyanins
Carboxymethyl starch
Bioactive agent delivery
Monolithic tablets
Syzygium cumini
topic Anthocyanins
Carboxymethyl starch
Bioactive agent delivery
Monolithic tablets
Syzygium cumini
description Anthocyanins obtained from jambolan have been used as active agents in different carboxymethyl starch-based tablet formulations and their release profiles evaluated in simulated gastric fluids (SGF) and simulated intestinal (SIF) fluids. Structural analysis highlighted a strong interaction between anthocyanins and carboxymethyl starch, evidenced by scanning electron microscopy and infrared analysis. Tablet dissolution behavior varied according to the pH of the media, being controlled by the swelling and/or erosion of the polymeric matrix. Various formulations for immediate, fast, and sustained release of anthocyanins for 30 min, 2 h and 12 h of dissolution have been developed. It was found that monolithic carboxymethyl starch tablets loaded with powdered jambolan extract efficiently afforded the complete delivery (100% of anthocyanins) to different sites of the simulated gastrointestinal tract and ensured the stability of these pigments, which maintained their antioxidant activity.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-11-25T14:26:17Z
dc.date.available.fl_str_mv 2022-11-25T14:26:17Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA JÚNIOR, I. J. et al. Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery. Molecules, [s.l.], v. 27, n. 21, 2022. DOI: https://doi.org/10.3390/molecules27217271
dc.identifier.uri.fl_str_mv http://www.repositorio.ufc.br/handle/riufc/69546
dc.identifier.issn.none.fl_str_mv 1420-3049
identifier_str_mv SILVA JÚNIOR, I. J. et al. Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery. Molecules, [s.l.], v. 27, n. 21, 2022. DOI: https://doi.org/10.3390/molecules27217271
1420-3049
url http://www.repositorio.ufc.br/handle/riufc/69546
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Molecules
publisher.none.fl_str_mv Molecules
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
bitstream.url.fl_str_mv http://repositorio.ufc.br/bitstream/riufc/69546/2/license.txt
http://repositorio.ufc.br/bitstream/riufc/69546/1/2022_art_ijsj%c3%banior.pdf
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repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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spelling 2022-11-25T14:26:17Z2022-11-25T14:26:17Z2022SILVA JÚNIOR, I. J. et al. Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery. Molecules, [s.l.], v. 27, n. 21, 2022. DOI: https://doi.org/10.3390/molecules272172711420-3049http://www.repositorio.ufc.br/handle/riufc/69546Anthocyanins obtained from jambolan have been used as active agents in different carboxymethyl starch-based tablet formulations and their release profiles evaluated in simulated gastric fluids (SGF) and simulated intestinal (SIF) fluids. Structural analysis highlighted a strong interaction between anthocyanins and carboxymethyl starch, evidenced by scanning electron microscopy and infrared analysis. Tablet dissolution behavior varied according to the pH of the media, being controlled by the swelling and/or erosion of the polymeric matrix. Various formulations for immediate, fast, and sustained release of anthocyanins for 30 min, 2 h and 12 h of dissolution have been developed. It was found that monolithic carboxymethyl starch tablets loaded with powdered jambolan extract efficiently afforded the complete delivery (100% of anthocyanins) to different sites of the simulated gastrointestinal tract and ensured the stability of these pigments, which maintained their antioxidant activity.MoleculesAnthocyaninsCarboxymethyl starchBioactive agent deliveryMonolithic tabletsSyzygium cuminiAnthocyanins formulated with carboxymethyl starch for gastric and intestinal deliveryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccessSabino, Luiz Bruno de SousaCopes, FrancescoSaulais, SolèneBrito, Edy Sousa deSilva Júnior, Ivanildo José daLe, Tien CanhMateescu, Mircea AlexandruMantovani, DiegoLICENSElicense.txtlicense.txttext/plain; charset=utf-82152http://repositorio.ufc.br/bitstream/riufc/69546/2/license.txtfb3ad2d23d9790966439580114baefafMD52ORIGINAL2022_art_ijsjúnior.pdf2022_art_ijsjúnior.pdfapplication/pdf4069085http://repositorio.ufc.br/bitstream/riufc/69546/1/2022_art_ijsj%c3%banior.pdf1ec5ad4358a70c5651ea0aa3df1025deMD51riufc/695462022-11-25 11:26:17.276oai:repositorio.ufc.br:riufc/69546TElDRU7Dh0EgREUgQVJNQVpFTkFNRU5UTyBFIERJU1RSSUJVScOHw4NPIE7Dg08tRVhDTFVTSVZBIAoKQW8gY29uY29yZGFyIGNvbSBlc3RhIGxpY2Vuw6dhLCB2b2PDqihzKSBhdXRvcihlcykgb3UgdGl0dWxhcihlcykgZG9zIGRpcmVpdG9zIGF1dG9yYWlzIGRhIG9icmEgYXF1aSBkZXNjcml0YSBjb25jZWRlKG0pIMOgIFVuaXZlcnNpZGFkZSBGZWRlcmFsIGRvIENlYXLDoSwgZ2VzdG9yYSBkbyBSZXBvc2l0w7NyaW8gSW5zdGl0dWNpb25hbCBkYSBVRkMgLSBSSS9VRkMsIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSByZXByb2R1emlyLCBjb252ZXJ0ZXIgKGNvbW8gZGVmaW5pZG8gYWJhaXhvKSBlL291IGRpc3RyaWJ1aXIgbyBkb2N1bWVudG8gZGVwb3NpdGFkbyBlbSBmb3JtYXRvIGltcHJlc3NvLCBlbGV0csO0bmljbyBvdSBlbSBxdWFscXVlciBvdXRybyBtZWlvLiBWb2PDqiBjb25jb3JkYShtKSBxdWUgYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkbyBDZWFyw6EsIGdlc3RvcmEgZG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgVUZDIC0gUkkvVUZDLCBwb2RlLCBzZW0gYWx0ZXJhciBvIGNvbnRlw7pkbywgY29udmVydGVyIG8gYXJxdWl2byBkZXBvc2l0YWRvIGEgcXVhbHF1ZXIgbWVpbyBvdSBmb3JtYXRvIGNvbSBmaW5zIGRlIHByZXNlcnZhw6fDo28uIFZvY8OqKHMpIHRhbWLDqW0gY29uY29yZGEobSkgcXVlIGEgVW5pdmVyc2lkYWRlIEZlZGVyYWwgZG8gQ2VhcsOhLCBnZXN0b3JhIGRvIFJlcG9zaXTDs3JpbyBJbnN0aXR1Y2lvbmFsIGRhIFVGQyAtIFJJL1VGQywgcG9kZSBtYW50ZXIgbWFpcyBkZSB1bWEgY8OzcGlhIGRlc3RlIGRlcMOzc2l0byBwYXJhIGZpbnMgZGUgc2VndXJhbsOnYSwgYmFjay11cCBlL291IHByZXNlcnZhw6fDo28uIFZvY8OqIGRlY2xhcmEgcXVlIGEgYXByZXNlbnRhw6fDo28gZG8gc2V1IHRyYWJhbGhvIMOpIG9yaWdpbmFsIGUgcXVlIHZvY8OqKHMpIHBvZGUobSkgY29uY2VkZXIgb3MgZGlyZWl0b3MgY29udGlkb3MgbmVzdGEgbGljZW7Dp2EuIFZvY8OqIHRhbWLDqW0gZGVjbGFyYShtKSBxdWUgbyBlbnZpbyDDqSBkZSBzZXUgY29uaGVjaW1lbnRvIGUgbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBhdXRvcmFpcyBkZSBvdXRyYSBwZXNzb2Egb3UgaW5zdGl0dWnDp8Ojby4gQ2FzbyBvIGRvY3VtZW50byBhIHNlciBkZXBvc2l0YWRvIGNvbnRlbmhhIG1hdGVyaWFsIHBhcmEgbyBxdWFsIHZvY8OqKHMpIG7Do28gZGV0w6ltIGEgdGl0dWxhcmlkYWRlIGRvcyBkaXJlaXRvcyBkZSBhdXRvcmFpcywgdm9jw6oocykgZGVjbGFyYShtKSBxdWUgb2J0ZXZlIGEgcGVybWlzc8OjbyBpcnJlc3RyaXRhIGRvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGF1dG9yYWlzIGRlIGNvbmNlZGVyIMOgIFVuaXZlcnNpZGFkZSBGZWRlcmFsIGRvIENlYXLDoSwgZ2VzdG9yYSBkbyBSZXBvc2l0w7NyaW8gSW5zdGl0dWNpb25hbCBkYSBVRkMgLSBSSS9VRkMsIG9zIGRpcmVpdG9zIHJlcXVlcmlkb3MgcG9yIGVzdGEgbGljZW7Dp2EgZSBxdWUgb3MgbWF0ZXJpYWlzIGRlIHByb3ByaWVkYWRlIGRlIHRlcmNlaXJvcywgZXN0w6NvIGRldmlkYW1lbnRlIGlkZW50aWZpY2Fkb3MgZSByZWNvbmhlY2lkb3Mgbm8gdGV4dG8gb3UgY29udGXDumRvIGRhIGFwcmVzZW50YcOnw6NvLgogQ0FTTyBPIFRSQUJBTEhPIERFUE9TSVRBRE8gVEVOSEEgU0lETyBGSU5BTkNJQURPIE9VIEFQT0lBRE8gUE9SIFVNIMOTUkfDg08sIFFVRSBOw4NPIEEgSU5TVElUVUnDh8ODTyBERVNURSBSRVBPU0lUw5NSSU86IFZPQ8OKIERFQ0xBUkEgVEVSIENVTVBSSURPIFRPRE9TIE9TIERJUkVJVE9TIERFIFJFVklTw4NPIEUgUVVBSVNRVUVSIE9VVFJBUyBPQlJJR0HDh8OVRVMgUkVRVUVSSURBUyBQRUxPIENPTlRSQVRPIE9VIEFDT1JETy4gCk8gcmVwb3NpdMOzcmlvIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvIHNldShzKSBub21lKHMpIGNvbW8gYXV0b3IoZXMpIG91IHRpdHVsYXIoZXMpIGRvIGRpcmVpdG8gZGUgYXV0b3IoZXMpIGRvIGRvY3VtZW50byBzdWJtZXRpZG8gZSBkZWNsYXJhIHF1ZSBuw6NvIGZhcsOhIHF1YWxxdWVyIGFsdGVyYcOnw6NvIGFsw6ltIGRhcyBwZXJtaXRpZGFzIHBvciBlc3RhIGxpY2Vuw6dhLgpSZXBvc2l0w7NyaW8gSW5zdGl0dWNpb25hbCBkYSBVRkMuCg==Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2022-11-25T14:26:17Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
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