Designing silver nanoparticles for detecting levodopa (3,4-dihydroxyphenylalanine, l-dopa) using surface-enhanced raman scattering (SERS)

Detection of the drug Levodopa (3,4-dihydroxyphenylalanine, L-Dopa) is essential for the medical treatment of several neural disorders, including Parkinson’s disease. In this paper, we employed surface-enhanced Raman scattering (SERS) with three shapes of silver nanoparticles (nanostars, AgNS; nanos...

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Detalles Bibliográficos
Autores: Rubira, Rafael Jesus Gonçalves [UNESP], Camacho, Sabrina Alessio [UNESP], Martin, Cibely Silva [UNESP], Mejía-Salazar, Jorge Ricardo, Gómez, Faustino Reyes, da Silva, Robson Rosa, de Oliveira Junior, Osvaldo Novais, Alessio, Priscila [UNESP], Constantino, Carlos José Leopoldo [UNESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Brasil
Institución:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/201422
Acceso en línea:http://dx.doi.org/10.3390/s20010015
http://hdl.handle.net/11449/201422
Access Level:acceso abierto
Palabra clave:Ag nanoparticles
L-Dopa
Multidimensional projections
SERS
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spelling Designing silver nanoparticles for detecting levodopa (3,4-dihydroxyphenylalanine, l-dopa) using surface-enhanced raman scattering (SERS)Ag nanoparticlesL-DopaMultidimensional projectionsSERSDetection of the drug Levodopa (3,4-dihydroxyphenylalanine, L-Dopa) is essential for the medical treatment of several neural disorders, including Parkinson’s disease. In this paper, we employed surface-enhanced Raman scattering (SERS) with three shapes of silver nanoparticles (nanostars, AgNS; nanospheres, AgNP; and nanoplates, AgNPL) to detect L-Dopa in the nanoparticle dispersions. The sensitivity of the L-Dopa SERS signal depended on both nanoparticle shape and L-Dopa concentration. The adsorption mechanisms of L-Dopa on the nanoparticles inferred from a detailed analysis of the Raman spectra allowed us to determine the chemical groups involved. For instance, at concentrations below/equivalent to the limit found in human plasma (between 10−7–10−8 mol/L), L-Dopa adsorbs on AgNP through its ring, while at 10−5–10−6 mol/L adsorption is driven by the amino group. At even higher concentrations, above 10−4 mol/L, L-Dopa polymerization predominates. Therefore, our results show that adsorption depends on both the type of Ag nanoparticles (shape and chemical groups surrounding the Ag surface) and the L-Dopa concentration. The overall strategy based on SERS is a step forward to the design of nanostructures to detect analytes of clinical interest with high specificity and at varied concentration ranges.Ministério da Ciência, Tecnologia, Inovações e ComunicaçõesFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)School of Technology and Applied Sciences São Paulo State University (UNESP)School of Sciences Humanities and Languages São Paulo State University (UNESP)National Institute of Telecommunications (Inatel), Santa Rita do SapucaíSão Carlos Institute of Physics University of São Paulo (USP), P.O. Box 369School of Technology and Applied Sciences São Paulo State University (UNESP)School of Sciences Humanities and Languages São Paulo State University (UNESP)Ministério da Ciência, Tecnologia, Inovações e Comunicações: 01250.075413/2018-04FAPESP: 2013/14262-7FAPESP: 2016/09634-0FAPESP: 2017/06534-8FAPESP: 2017/15019-0FAPESP: 2018/04628-8FAPESP: 2018/14692-5CAPES: 305958/2018-6CNPq: 305958/2018-6CAPES: 422163/2018-0CNPq: 422163/2018-0CAPES: 429496/2018-4CNPq: 429496/2018-4Universidade Estadual Paulista (Unesp)National Institute of Telecommunications (Inatel)Universidade de São Paulo (USP)2020-12-12T02:32:05Z2020-12-12T02:32:05Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/s20010015Sensors (Switzerland), v. 20, n. 1, 2020.1424-8220http://hdl.handle.net/11449/20142210.3390/s200100152-s2.0-85076946534Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengSensors (Switzerland)info:eu-repo/semantics/openAccessRubira, Rafael Jesus Gonçalves [UNESP]Camacho, Sabrina Alessio [UNESP]Martin, Cibely Silva [UNESP]Mejía-Salazar, Jorge RicardoGómez, Faustino Reyesda Silva, Robson Rosade Oliveira Junior, Osvaldo NovaisAlessio, Priscila [UNESP]Constantino, Carlos José Leopoldo [UNESP]2024-06-19T12:44:22Zoai:repositorio.unesp.br:11449/201422Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-06-19T12:44:22Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Designing silver nanoparticles for detecting levodopa (3,4-dihydroxyphenylalanine, l-dopa) using surface-enhanced raman scattering (SERS)
title Designing silver nanoparticles for detecting levodopa (3,4-dihydroxyphenylalanine, l-dopa) using surface-enhanced raman scattering (SERS)
spellingShingle Designing silver nanoparticles for detecting levodopa (3,4-dihydroxyphenylalanine, l-dopa) using surface-enhanced raman scattering (SERS)
Rubira, Rafael Jesus Gonçalves [UNESP]
Ag nanoparticles
L-Dopa
Multidimensional projections
SERS
title_short Designing silver nanoparticles for detecting levodopa (3,4-dihydroxyphenylalanine, l-dopa) using surface-enhanced raman scattering (SERS)
title_full Designing silver nanoparticles for detecting levodopa (3,4-dihydroxyphenylalanine, l-dopa) using surface-enhanced raman scattering (SERS)
title_fullStr Designing silver nanoparticles for detecting levodopa (3,4-dihydroxyphenylalanine, l-dopa) using surface-enhanced raman scattering (SERS)
title_full_unstemmed Designing silver nanoparticles for detecting levodopa (3,4-dihydroxyphenylalanine, l-dopa) using surface-enhanced raman scattering (SERS)
title_sort Designing silver nanoparticles for detecting levodopa (3,4-dihydroxyphenylalanine, l-dopa) using surface-enhanced raman scattering (SERS)
dc.creator.none.fl_str_mv Rubira, Rafael Jesus Gonçalves [UNESP]
Camacho, Sabrina Alessio [UNESP]
Martin, Cibely Silva [UNESP]
Mejía-Salazar, Jorge Ricardo
Gómez, Faustino Reyes
da Silva, Robson Rosa
de Oliveira Junior, Osvaldo Novais
Alessio, Priscila [UNESP]
Constantino, Carlos José Leopoldo [UNESP]
author Rubira, Rafael Jesus Gonçalves [UNESP]
author_facet Rubira, Rafael Jesus Gonçalves [UNESP]
Camacho, Sabrina Alessio [UNESP]
Martin, Cibely Silva [UNESP]
Mejía-Salazar, Jorge Ricardo
Gómez, Faustino Reyes
da Silva, Robson Rosa
de Oliveira Junior, Osvaldo Novais
Alessio, Priscila [UNESP]
Constantino, Carlos José Leopoldo [UNESP]
author_role author
author2 Camacho, Sabrina Alessio [UNESP]
Martin, Cibely Silva [UNESP]
Mejía-Salazar, Jorge Ricardo
Gómez, Faustino Reyes
da Silva, Robson Rosa
de Oliveira Junior, Osvaldo Novais
Alessio, Priscila [UNESP]
Constantino, Carlos José Leopoldo [UNESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
National Institute of Telecommunications (Inatel)
Universidade de São Paulo (USP)
dc.subject.por.fl_str_mv Ag nanoparticles
L-Dopa
Multidimensional projections
SERS
topic Ag nanoparticles
L-Dopa
Multidimensional projections
SERS
description Detection of the drug Levodopa (3,4-dihydroxyphenylalanine, L-Dopa) is essential for the medical treatment of several neural disorders, including Parkinson’s disease. In this paper, we employed surface-enhanced Raman scattering (SERS) with three shapes of silver nanoparticles (nanostars, AgNS; nanospheres, AgNP; and nanoplates, AgNPL) to detect L-Dopa in the nanoparticle dispersions. The sensitivity of the L-Dopa SERS signal depended on both nanoparticle shape and L-Dopa concentration. The adsorption mechanisms of L-Dopa on the nanoparticles inferred from a detailed analysis of the Raman spectra allowed us to determine the chemical groups involved. For instance, at concentrations below/equivalent to the limit found in human plasma (between 10−7–10−8 mol/L), L-Dopa adsorbs on AgNP through its ring, while at 10−5–10−6 mol/L adsorption is driven by the amino group. At even higher concentrations, above 10−4 mol/L, L-Dopa polymerization predominates. Therefore, our results show that adsorption depends on both the type of Ag nanoparticles (shape and chemical groups surrounding the Ag surface) and the L-Dopa concentration. The overall strategy based on SERS is a step forward to the design of nanostructures to detect analytes of clinical interest with high specificity and at varied concentration ranges.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T02:32:05Z
2020-12-12T02:32:05Z
2020-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/s20010015
Sensors (Switzerland), v. 20, n. 1, 2020.
1424-8220
http://hdl.handle.net/11449/201422
10.3390/s20010015
2-s2.0-85076946534
url http://dx.doi.org/10.3390/s20010015
http://hdl.handle.net/11449/201422
identifier_str_mv Sensors (Switzerland), v. 20, n. 1, 2020.
1424-8220
10.3390/s20010015
2-s2.0-85076946534
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Sensors (Switzerland)
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1853671538222432256
score 15,301629

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