Short-term cross-sensitizion of need-free sugar intake by combining sodium depletion and hypertonic NaCl intake
History of sodium depletion cross-sensitizes the effects of drugs of abuse. The objective of the present study was to find out if history of sodium depletion also cross-sensitizes a natural reward such as sugar intake in the rat. Sodium depletion was induced by furosemide combined with removal of am...
| Autores: | , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/173310 |
| Acceso en línea: | http://dx.doi.org/10.1016/j.appet.2016.07.020 http://hdl.handle.net/11449/173310 |
| Access Level: | acceso abierto |
| Palabra clave: | Behavioral sensitization Dehydration Neuroplasticity Reward Sodium appetite Thirst |
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Short-term cross-sensitizion of need-free sugar intake by combining sodium depletion and hypertonic NaCl intakeBehavioral sensitizationDehydrationNeuroplasticityRewardSodium appetiteThirstHistory of sodium depletion cross-sensitizes the effects of drugs of abuse. The objective of the present study was to find out if history of sodium depletion also cross-sensitizes a natural reward such as sugar intake in the rat. Sodium depletion was induced by furosemide combined with removal of ambient sodium for 24 h; it was repeated seven days later. The depletion was immediately followed by 0.3 M NaCl intake in a sodium appetite test (active sodium repletion). Seven days after the last depletion, hydrated and fed (need-free) sucrose-naïve animals were offered 10% sucrose in a first 2-h sucrose test. The sucrose test was repeated once a day in a series of five consecutive days. History of sodium depletion enhanced sucrose intake in the first and second tests; it had no effect from the third to fifth sucrose test. The effect on the initial sucrose intake tests disappeared if the rats did not ingest 0.3 M NaCl in the sodium appetite test. Prior experience with sucrose intake in need-free conditions had no effect on sodium appetite. History of intracellular dehydration transiently influenced sucrose intake in the first sucrose test. We found no evidence for thirst sensitization. We conclude that history of dehydration, particularly that resulting from sodium depletion, combined to active sodium repletion, produced short-term cross-sensitization of sucrose intake in sucrose-naïve rats. The results suggest that the cross-sensitization of sucrose intake related with acquisition of sugar as a novel nutrient rather than production of lasting effects on sugar rewarding properties.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Physiology and Pathology School of Dentistry-FOAr São Paulo State University – UNESPDepartment of Physiology and Pathology School of Dentistry-FOAr São Paulo State University – UNESPFAPESP: 11/50770–1Universidade Estadual Paulista (Unesp)2018-12-11T17:04:36Z2018-12-11T17:04:36Z2016-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article79-85application/pdfhttp://dx.doi.org/10.1016/j.appet.2016.07.020Appetite, v. 107, p. 79-85.1095-83040195-6663http://hdl.handle.net/11449/17331010.1016/j.appet.2016.07.0202-s2.0-849797745662-s2.0-84979774566.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAppetite1,4411,441info:eu-repo/semantics/openAccessSantos, Bruna M. [UNESP]de Andrade, Carina A.F. [UNESP]Menani, José V. [UNESP]De Luca, Laurival A. [UNESP]2025-04-18T09:42:46Zoai:repositorio.unesp.br:11449/173310Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-04-18T09:42:46Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Short-term cross-sensitizion of need-free sugar intake by combining sodium depletion and hypertonic NaCl intake |
| title |
Short-term cross-sensitizion of need-free sugar intake by combining sodium depletion and hypertonic NaCl intake |
| spellingShingle |
Short-term cross-sensitizion of need-free sugar intake by combining sodium depletion and hypertonic NaCl intake Santos, Bruna M. [UNESP] Behavioral sensitization Dehydration Neuroplasticity Reward Sodium appetite Thirst |
| title_short |
Short-term cross-sensitizion of need-free sugar intake by combining sodium depletion and hypertonic NaCl intake |
| title_full |
Short-term cross-sensitizion of need-free sugar intake by combining sodium depletion and hypertonic NaCl intake |
| title_fullStr |
Short-term cross-sensitizion of need-free sugar intake by combining sodium depletion and hypertonic NaCl intake |
| title_full_unstemmed |
Short-term cross-sensitizion of need-free sugar intake by combining sodium depletion and hypertonic NaCl intake |
| title_sort |
Short-term cross-sensitizion of need-free sugar intake by combining sodium depletion and hypertonic NaCl intake |
| dc.creator.none.fl_str_mv |
Santos, Bruna M. [UNESP] de Andrade, Carina A.F. [UNESP] Menani, José V. [UNESP] De Luca, Laurival A. [UNESP] |
| author |
Santos, Bruna M. [UNESP] |
| author_facet |
Santos, Bruna M. [UNESP] de Andrade, Carina A.F. [UNESP] Menani, José V. [UNESP] De Luca, Laurival A. [UNESP] |
| author_role |
author |
| author2 |
de Andrade, Carina A.F. [UNESP] Menani, José V. [UNESP] De Luca, Laurival A. [UNESP] |
| author2_role |
author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
| dc.subject.por.fl_str_mv |
Behavioral sensitization Dehydration Neuroplasticity Reward Sodium appetite Thirst |
| topic |
Behavioral sensitization Dehydration Neuroplasticity Reward Sodium appetite Thirst |
| description |
History of sodium depletion cross-sensitizes the effects of drugs of abuse. The objective of the present study was to find out if history of sodium depletion also cross-sensitizes a natural reward such as sugar intake in the rat. Sodium depletion was induced by furosemide combined with removal of ambient sodium for 24 h; it was repeated seven days later. The depletion was immediately followed by 0.3 M NaCl intake in a sodium appetite test (active sodium repletion). Seven days after the last depletion, hydrated and fed (need-free) sucrose-naïve animals were offered 10% sucrose in a first 2-h sucrose test. The sucrose test was repeated once a day in a series of five consecutive days. History of sodium depletion enhanced sucrose intake in the first and second tests; it had no effect from the third to fifth sucrose test. The effect on the initial sucrose intake tests disappeared if the rats did not ingest 0.3 M NaCl in the sodium appetite test. Prior experience with sucrose intake in need-free conditions had no effect on sodium appetite. History of intracellular dehydration transiently influenced sucrose intake in the first sucrose test. We found no evidence for thirst sensitization. We conclude that history of dehydration, particularly that resulting from sodium depletion, combined to active sodium repletion, produced short-term cross-sensitization of sucrose intake in sucrose-naïve rats. The results suggest that the cross-sensitization of sucrose intake related with acquisition of sugar as a novel nutrient rather than production of lasting effects on sugar rewarding properties. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016-12-01 2018-12-11T17:04:36Z 2018-12-11T17:04:36Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.appet.2016.07.020 Appetite, v. 107, p. 79-85. 1095-8304 0195-6663 http://hdl.handle.net/11449/173310 10.1016/j.appet.2016.07.020 2-s2.0-84979774566 2-s2.0-84979774566.pdf |
| url |
http://dx.doi.org/10.1016/j.appet.2016.07.020 http://hdl.handle.net/11449/173310 |
| identifier_str_mv |
Appetite, v. 107, p. 79-85. 1095-8304 0195-6663 10.1016/j.appet.2016.07.020 2-s2.0-84979774566 2-s2.0-84979774566.pdf |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Appetite 1,441 1,441 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
79-85 application/pdf |
| dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
| instname_str |
Universidade Estadual Paulista (UNESP) |
| instacron_str |
UNESP |
| institution |
UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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repositoriounesp@unesp.br |
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1853672294387286016 |
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15,300719 |