Microbial astaxanthin-encapsulated polymeric micelles from yeast Phaffia rhodozyma for personalized bioactive colored natural rubber latex bandages

Mussagy, Cassamo U.; Dias, Júlia N. [UNESP]; Caicedo-Paz, Angie V.; Gini, Ana L.R. [UNESP]; Scarim, Cauê B. [UNESP]; Tropea, Alessia; La Tella, Roberta; Mondello, Luigi; Lopes-Filho, Paulo E.L. [UNESP]; Tanaka, Jean L. [UNESP]; Piazza, Rodolfo D. [UNESP]; Marques, Rodrigo F.C. [UNESP]; Santos, Lindomar S.; Luiz, Marcela T. [UNESP]; Chorilli, Marlus [UNESP]; Santos-Ebinuma, Valéria C. [UNESP]; Pessoa, Adalberto; Herculano, Rondinelli D. [UNESP]

Microbial astaxanthin-encapsulated polymeric micelles from yeast Phaffia rhodozyma for personalized bioactive colored natural rubber latex bandages

This study explores the development of bioactive, colored natural rubber latex (NRL) bandages by incorporating astaxanthin (AXT), a carotenoid with potent antioxidant and anti-inflammatory properties. AXT is produced by the yeast Phaffia rhodozyma under various light conditions to improve AXT biosyn...

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Authors:	Mussagy, Cassamo U., Dias, Júlia N. [UNESP], Caicedo-Paz, Angie V., Gini, Ana L.R. [UNESP], Scarim, Cauê B. [UNESP], Tropea, Alessia, La Tella, Roberta, Mondello, Luigi, Lopes-Filho, Paulo E.L. [UNESP], Tanaka, Jean L. [UNESP], Piazza, Rodolfo D. [UNESP], Marques, Rodrigo F.C. [UNESP], Santos, Lindomar S., Luiz, Marcela T. [UNESP], Chorilli, Marlus [UNESP], Santos-Ebinuma, Valéria C. [UNESP], Pessoa, Adalberto, Herculano, Rondinelli D. [UNESP]
Format:	article
Status:	Published version
Publication Date:	2025
Country:	Brasil
Institution:	Universidade Estadual Paulista (UNESP)
Repository:	Repositório Institucional da UNESP
Language:	English
OAI Identifier:	oai:repositorio.unesp.br:11449/300691
Online Access:	http://dx.doi.org/10.1016/j.ijbiomac.2025.141078 https://hdl.handle.net/11449/300691
Access Level:	Open access
Keyword:	Astaxanthin Bandages Biocompatibility Coloring Natural rubber latex Phaffia rhodozyma Polymeric micelles

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oai_identifier_str	oai:repositorio.unesp.br:11449/300691
network_acronym_str	BR
network_name_str	Brasil
repository_id_str
dc.title.none.fl_str_mv	Microbial astaxanthin-encapsulated polymeric micelles from yeast Phaffia rhodozyma for personalized bioactive colored natural rubber latex bandages
title	Microbial astaxanthin-encapsulated polymeric micelles from yeast Phaffia rhodozyma for personalized bioactive colored natural rubber latex bandages
spellingShingle	Microbial astaxanthin-encapsulated polymeric micelles from yeast Phaffia rhodozyma for personalized bioactive colored natural rubber latex bandages Mussagy, Cassamo U. Astaxanthin Bandages Biocompatibility Coloring Natural rubber latex Phaffia rhodozyma Polymeric micelles
title_short	Microbial astaxanthin-encapsulated polymeric micelles from yeast Phaffia rhodozyma for personalized bioactive colored natural rubber latex bandages
title_full	Microbial astaxanthin-encapsulated polymeric micelles from yeast Phaffia rhodozyma for personalized bioactive colored natural rubber latex bandages
title_fullStr	Microbial astaxanthin-encapsulated polymeric micelles from yeast Phaffia rhodozyma for personalized bioactive colored natural rubber latex bandages
title_full_unstemmed	Microbial astaxanthin-encapsulated polymeric micelles from yeast Phaffia rhodozyma for personalized bioactive colored natural rubber latex bandages
title_sort	Microbial astaxanthin-encapsulated polymeric micelles from yeast Phaffia rhodozyma for personalized bioactive colored natural rubber latex bandages
dc.creator.none.fl_str_mv	Mussagy, Cassamo U. Dias, Júlia N. [UNESP] Caicedo-Paz, Angie V. Gini, Ana L.R. [UNESP] Scarim, Cauê B. [UNESP] Tropea, Alessia La Tella, Roberta Mondello, Luigi Lopes-Filho, Paulo E.L. [UNESP] Tanaka, Jean L. [UNESP] Piazza, Rodolfo D. [UNESP] Marques, Rodrigo F.C. [UNESP] Santos, Lindomar S. Luiz, Marcela T. [UNESP] Chorilli, Marlus [UNESP] Santos-Ebinuma, Valéria C. [UNESP] Pessoa, Adalberto Herculano, Rondinelli D. [UNESP]
author	Mussagy, Cassamo U.
author_facet	Mussagy, Cassamo U. Dias, Júlia N. [UNESP] Caicedo-Paz, Angie V. Gini, Ana L.R. [UNESP] Scarim, Cauê B. [UNESP] Tropea, Alessia La Tella, Roberta Mondello, Luigi Lopes-Filho, Paulo E.L. [UNESP] Tanaka, Jean L. [UNESP] Piazza, Rodolfo D. [UNESP] Marques, Rodrigo F.C. [UNESP] Santos, Lindomar S. Luiz, Marcela T. [UNESP] Chorilli, Marlus [UNESP] Santos-Ebinuma, Valéria C. [UNESP] Pessoa, Adalberto Herculano, Rondinelli D. [UNESP]
author_role	author
author2	Dias, Júlia N. [UNESP] Caicedo-Paz, Angie V. Gini, Ana L.R. [UNESP] Scarim, Cauê B. [UNESP] Tropea, Alessia La Tella, Roberta Mondello, Luigi Lopes-Filho, Paulo E.L. [UNESP] Tanaka, Jean L. [UNESP] Piazza, Rodolfo D. [UNESP] Marques, Rodrigo F.C. [UNESP] Santos, Lindomar S. Luiz, Marcela T. [UNESP] Chorilli, Marlus [UNESP] Santos-Ebinuma, Valéria C. [UNESP] Pessoa, Adalberto Herculano, Rondinelli D. [UNESP]
author2_role	author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Pontificia Universidad Católica de Valparaíso Universidade Estadual Paulista (UNESP) University of Messina Universidade de São Paulo (USP) Terasaki Institute for Biomedical Innovation (TIBI)
dc.subject.por.fl_str_mv	Astaxanthin Bandages Biocompatibility Coloring Natural rubber latex Phaffia rhodozyma Polymeric micelles
topic	Astaxanthin Bandages Biocompatibility Coloring Natural rubber latex Phaffia rhodozyma Polymeric micelles
description	This study explores the development of bioactive, colored natural rubber latex (NRL) bandages by incorporating astaxanthin (AXT), a carotenoid with potent antioxidant and anti-inflammatory properties. AXT is produced by the yeast Phaffia rhodozyma under various light conditions to improve AXT biosynthesis and encapsulated in polymeric micelles to enhance its solubility and stability. The encapsulated AXT is then integrated into NRL bandages, imparting a orange-red hue and potentially therapeutic benefits. Physicochemical characterizations, including UV–Vis spectroscopy and FTIR, reveal interactions between AXT and the micelle components. The bandages exhibit improved hydrophilicity and maintain their thermal stability post-AXT incorporation. Antioxidant capacity assessments show that the NRL bandages retain a significant portion of AXT's antioxidant properties, which can aid in wound healing. The release profile of AXT from the bandages demonstrates an initial burst followed by sustained release, indicating effective delivery of the carotenoid. This innovative approach combines aesthetic appeal with biomedical advantages, offering a personalized solution for wound care applications.
publishDate	2025
dc.date.none.fl_str_mv	2025-04-29T18:50:20Z 2025-05-01
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.uri.fl_str_mv	http://dx.doi.org/10.1016/j.ijbiomac.2025.141078 International Journal of Biological Macromolecules, v. 305. 1879-0003 0141-8130 https://hdl.handle.net/11449/300691 10.1016/j.ijbiomac.2025.141078 2-s2.0-85217923851
url	http://dx.doi.org/10.1016/j.ijbiomac.2025.141078 https://hdl.handle.net/11449/300691
identifier_str_mv	International Journal of Biological Macromolecules, v. 305. 1879-0003 0141-8130 10.1016/j.ijbiomac.2025.141078 2-s2.0-85217923851
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	International Journal of Biological Macromolecules
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.source.none.fl_str_mv	Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP
instname_str	Universidade Estadual Paulista (UNESP)
instacron_str	UNESP
institution	UNESP
reponame_str	Repositório Institucional da UNESP
collection	Repositório Institucional da UNESP
repository.name.fl_str_mv	Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv	repositoriounesp@unesp.br
_version_	1853672144702013440
spelling	Microbial astaxanthin-encapsulated polymeric micelles from yeast Phaffia rhodozyma for personalized bioactive colored natural rubber latex bandagesAstaxanthinBandagesBiocompatibilityColoringNatural rubber latexPhaffia rhodozymaPolymeric micellesThis study explores the development of bioactive, colored natural rubber latex (NRL) bandages by incorporating astaxanthin (AXT), a carotenoid with potent antioxidant and anti-inflammatory properties. AXT is produced by the yeast Phaffia rhodozyma under various light conditions to improve AXT biosynthesis and encapsulated in polymeric micelles to enhance its solubility and stability. The encapsulated AXT is then integrated into NRL bandages, imparting a orange-red hue and potentially therapeutic benefits. Physicochemical characterizations, including UV–Vis spectroscopy and FTIR, reveal interactions between AXT and the micelle components. The bandages exhibit improved hydrophilicity and maintain their thermal stability post-AXT incorporation. Antioxidant capacity assessments show that the NRL bandages retain a significant portion of AXT's antioxidant properties, which can aid in wound healing. The release profile of AXT from the bandages demonstrates an initial burst followed by sustained release, indicating effective delivery of the carotenoid. This innovative approach combines aesthetic appeal with biomedical advantages, offering a personalized solution for wound care applications.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Escuela de Agronomía Facultad de Ciencias Agronómicas y de los Alimentos Pontificia Universidad Católica de ValparaísoSão Paulo State University (UNESP) School of Pharmaceutical Sciences Department of Bioprocesses and Biotechnology, SPSão Paulo State University (UNESP) School of Pharmaceutical Sciences Department of Drugs and Medicines, SPMessina Institute of Technology c/o Department of Chemical Biological Pharmaceutical and Environmental Sciences former Veterinary School University of Messina, Viale G. Palatucci sncChromaleont s.r.l. c/o Department of Chemical Biological Pharmaceutical and Environmental Sciences University of Messina, viale AnnunziataBioengineering & Biomaterials Group São Paulo State University (UNESP) School of Pharmaceutical Sciences, SPLaboratory of Magnetic Materials and Colloids Department of Analytical Chemistry Physical Chemistry and Inorganic Institute of Chemistry São Paulo State University (UNESP), SPFaculty of Philosophy Sciences and Languages of Ribeirão Preto University of São Paulo (USP), 3900 Bandeirantes Avenue, SPDepartment of Pharmaceutical-Biochemical Technology School of Pharmaceutical Sciences University of São PauloTerasaki Institute for Biomedical Innovation (TIBI), 11507 W Olympic BlvdSão Paulo State University (UNESP) School of Pharmaceutical Sciences Department of Bioprocesses and Biotechnology, SPSão Paulo State University (UNESP) School of Pharmaceutical Sciences Department of Drugs and Medicines, SPBioengineering & Biomaterials Group São Paulo State University (UNESP) School of Pharmaceutical Sciences, SPLaboratory of Magnetic Materials and Colloids Department of Analytical Chemistry Physical Chemistry and Inorganic Institute of Chemistry São Paulo State University (UNESP), SPFAPESP: 2015/11759–3FAPESP: 2021/06686–8FAPESP: 2023/17448–6Pontificia Universidad Católica de ValparaísoUniversidade Estadual Paulista (UNESP)University of MessinaUniversidade de São Paulo (USP)Terasaki Institute for Biomedical Innovation (TIBI)2025-04-29T18:50:20Z2025-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.ijbiomac.2025.141078International Journal of Biological Macromolecules, v. 305.1879-00030141-8130https://hdl.handle.net/11449/30069110.1016/j.ijbiomac.2025.1410782-s2.0-85217923851Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Biological Macromoleculesinfo:eu-repo/semantics/openAccessMussagy, Cassamo U.Dias, Júlia N. [UNESP]Caicedo-Paz, Angie V.Gini, Ana L.R. [UNESP]Scarim, Cauê B. [UNESP]Tropea, AlessiaLa Tella, RobertaMondello, LuigiLopes-Filho, Paulo E.L. [UNESP]Tanaka, Jean L. [UNESP]Piazza, Rodolfo D. [UNESP]Marques, Rodrigo F.C. [UNESP]Santos, Lindomar S.Luiz, Marcela T. [UNESP]Chorilli, Marlus [UNESP]Santos-Ebinuma, Valéria C. [UNESP]Pessoa, AdalbertoHerculano, Rondinelli D. [UNESP]2025-05-28T06:49:07Zoai:repositorio.unesp.br:11449/300691Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-05-28T06:49:07Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
score	15,300724

Microbial astaxanthin-encapsulated polymeric micelles from yeast Phaffia rhodozyma for personalized bioactive colored natural rubber latex bandages

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