Microbial astaxanthin-encapsulated polymeric micelles from yeast Phaffia rhodozyma for personalized bioactive colored natural rubber latex bandages

This study explores the development of bioactive, colored natural rubber latex (NRL) bandages by incorporating astaxanthin (AXT), a carotenoid with potent antioxidant and anti-inflammatory properties. AXT is produced by the yeast Phaffia rhodozyma under various light conditions to improve AXT biosyn...

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Detalles Bibliográficos
Autores: Mussagy, Cassamo U., Dias, Júlia N. [UNESP], Caicedo-Paz, Angie V., Gini, Ana L.R. [UNESP], Scarim, Cauê B. [UNESP], Tropea, Alessia, La Tella, Roberta, Mondello, Luigi, Lopes-Filho, Paulo E.L. [UNESP], Tanaka, Jean L. [UNESP], Piazza, Rodolfo D. [UNESP], Marques, Rodrigo F.C. [UNESP], Santos, Lindomar S., Luiz, Marcela T. [UNESP], Chorilli, Marlus [UNESP], Santos-Ebinuma, Valéria C. [UNESP], Pessoa, Adalberto, Herculano, Rondinelli D. [UNESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:Brasil
Institución:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/300691
Acceso en línea:http://dx.doi.org/10.1016/j.ijbiomac.2025.141078
https://hdl.handle.net/11449/300691
Access Level:acceso abierto
Palabra clave:Astaxanthin
Bandages
Biocompatibility
Coloring
Natural rubber latex
Phaffia rhodozyma
Polymeric micelles
Descripción
Sumario:This study explores the development of bioactive, colored natural rubber latex (NRL) bandages by incorporating astaxanthin (AXT), a carotenoid with potent antioxidant and anti-inflammatory properties. AXT is produced by the yeast Phaffia rhodozyma under various light conditions to improve AXT biosynthesis and encapsulated in polymeric micelles to enhance its solubility and stability. The encapsulated AXT is then integrated into NRL bandages, imparting a orange-red hue and potentially therapeutic benefits. Physicochemical characterizations, including UV–Vis spectroscopy and FTIR, reveal interactions between AXT and the micelle components. The bandages exhibit improved hydrophilicity and maintain their thermal stability post-AXT incorporation. Antioxidant capacity assessments show that the NRL bandages retain a significant portion of AXT's antioxidant properties, which can aid in wound healing. The release profile of AXT from the bandages demonstrates an initial burst followed by sustained release, indicating effective delivery of the carotenoid. This innovative approach combines aesthetic appeal with biomedical advantages, offering a personalized solution for wound care applications.

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