Rapid Eye Movement Sleep Behavior Disorder in Paraneoplastic Cerebellar Degeneration: Improvement with Immunotherapy

Study Objectives: To report two female patients with paraneoplastic cerebellar degeneration (PCD) related to breast cancer that presented with rapid eye movement-sleep behavior disorder (RBD) and improved sleep symptoms with immunotherapy. Methods: The two patients were evaluated through clinical sc...

Full description

Bibliographic Details
Authors: Vale, Thiago Cardoso, Prado, Lucila Bizari Fernandes do [UNIFESP], Prado, Gilmar Fernandes do [UNIFESP], Barsottini, Orlando Graziani Povoas [UNIFESP], Pedroso, Jose Luiz [UNIFESP]
Format: article
Status:Published version
Publication Date:2016
Country:Brasil
Institution:Universidade Federal de São Paulo (UNIFESP)
Repository:Repositório Institucional da UNIFESP
Language:English
OAI Identifier:oai:repositorio.unifesp.br:11600/46068
Online Access:https://dx.doi.org/10.5665/sleep.5330
https://repositorio.unifesp.br/handle/11600/46068
Access Level:Open access
Keyword:Immunotherapy
Paraneoplastic cerebellar degeneration
REM sleep
REM-sleep behavior disorderRem-Sleep
Limbic Encephalitis
Antibodies
Ataxia
Description
Summary:Study Objectives: To report two female patients with paraneoplastic cerebellar degeneration (PCD) related to breast cancer that presented with rapid eye movement-sleep behavior disorder (RBD) and improved sleep symptoms with immunotherapy. Methods: The two patients were evaluated through clinical scale and polysomnography before and after therapy with intravenous immunoglobulin. Results: RBD was successfully treated with immunotherapy in both patients. Score on the RBD screening questionnaire dropped from 10 to 1 or 0, allied with the normalization of polysomnographic findings. Conclusions: A marked improvement in RBD after immunotherapy in PCD raises the hypothesis that secondary RBD may be an immune-mediated sleep disorder.

Similar Items