Paramyxoviruses from neotropical bats suggest a novel genus and nephrotropism

Paramyxoviruses have a broad host range and geographic distribution, including human pathogens transmitted by bats, such as Nipah and Hendra viruses. In this study, we combined high-throughput sequencing and molecular approaches to investigate the presence of paramyxoviruses in neotropical bats (Mic...

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Detalles Bibliográficos
Autores: Souza, William Marciel de, Fumagalli, Marcilio Jorge, Carrera, Jean Paul, Araújo, Jansen de, Cardoso, Jedson Ferreira, Carvalho, Cristiano de, Durigon, Edison Luiz, Queiroz, Luiza Helena, Faria, Nuno Rodrigues, Murcia, Pablo R, Figueiredo, Luiz Tadeu Moraes
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:Brasil
Institución:Instituto Evandro Chagas (IEC)
Repositorio:Repositório Digital do Instituto Evandro Chagas (Patuá)
Idioma:inglés
OAI Identifier:oai:patua.iec.gov.br:iec/4429
Acceso en línea:https://patua.iec.gov.br/handle/iec/4429
Access Level:acceso embargado
Palabra clave:Quirópteros / anatomia & histologia
Paramyxoviridae / isolamento & purificação
Quirópteros / virologia
Descripción
Sumario:Paramyxoviruses have a broad host range and geographic distribution, including human pathogens transmitted by bats, such as Nipah and Hendra viruses. In this study, we combined high-throughput sequencing and molecular approaches to investigate the presence of paramyxoviruses in neotropical bats (Microchiroptera suborder) in Brazil. We discovered and characterized three novel paramyxoviruses in the kidney tissues of apparently healthy common vampire bats (D. rotundus) and Seba's short-tailed bats (C. perspicillata), which we tentatively named Kanhgág virus (KANV), Boe virus (BOEV), and Guató virus (GUATV). In this study, we classified these viruses as putative species into the Macrojêvirus genus, a newly proposed genus of the Orthoparamyxovirinae subfamily. Using RT-PCR, we detected these viruses in 20.9% (9 out of 43) of bats tested, and viral RNA was detected exclusively in kidney tissues. Attempts to isolate infectious virus were successful for KANV and GUATV. Our results expand the viral diversity, host range, and geographical distribution of the paramyxoviruses.

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