Paramyxoviruses from neotropical bats suggest a novel genus and nephrotropism

Paramyxoviruses have a broad host range and geographic distribution, including human pathogens transmitted by bats, such as Nipah and Hendra viruses. In this study, we combined high-throughput sequencing and molecular approaches to investigate the presence of paramyxoviruses in neotropical bats (Mic...

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Detalles Bibliográficos
Autores: de Souza, William Marciel, Fumagalli, Marcilio Jorge, Carrera, Jean Paul, de Araujo, Jansen, Cardoso, Jedson Ferreira, de Carvalho, Cristiano [UNESP], Durigon, Edison Luiz, Queiroz, Luzia Helena [UNESP], Faria, Nuno Rodrigues, Murcia, Pablo R., Figueiredo, Luiz Tadeu Moraes
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:Brasil
Institución:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/233426
Acceso en línea:http://dx.doi.org/10.1016/j.meegid.2021.105041
http://hdl.handle.net/11449/233426
Access Level:acceso abierto
Palabra clave:Bat-borne diseases
Paramyxoviridae
Paramyxovirus
Virus discovery
Descripción
Sumario:Paramyxoviruses have a broad host range and geographic distribution, including human pathogens transmitted by bats, such as Nipah and Hendra viruses. In this study, we combined high-throughput sequencing and molecular approaches to investigate the presence of paramyxoviruses in neotropical bats (Microchiroptera suborder) in Brazil. We discovered and characterized three novel paramyxoviruses in the kidney tissues of apparently healthy common vampire bats (D. rotundus) and Seba's short-tailed bats (C. perspicillata), which we tentatively named Kanhgág virus (KANV), Boe virus (BOEV), and Guató virus (GUATV). In this study, we classified these viruses as putative species into the Macrojêvirus genus, a newly proposed genus of the Orthoparamyxovirinae subfamily. Using RT-PCR, we detected these viruses in 20.9% (9 out of 43) of bats tested, and viral RNA was detected exclusively in kidney tissues. Attempts to isolate infectious virus were successful for KANV and GUATV. Our results expand the viral diversity, host range, and geographical distribution of the paramyxoviruses.

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