Cocrystals of ciprofloxacin with nicotinic and isonicotinic acids: Mechanochemical synthesis, characterization, thermal and solubility study

This article describes the synthesis and characterization of new cocrystals of ciprofloxacin with nicotinic and isonicotinic acids as coformers. The cocrystals were obtained by a mechanochemical method (neat and liquid-assisted grinding). The characterization of the cocrystals was carried out using...

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Autores: de Almeida, Amanda Cosmo [UNESP], Torquetti, Carolina [UNESP], Ferreira, Patrícia Osório [UNESP], Fernandes, Richard Perosa [UNESP], dos Santos, Everton Carvalho [UNESP], Kogawa, Ana Carolina [UNESP], Caires, Flávio Junior [UNESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Brasil
Institución:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/198125
Acceso en línea:http://dx.doi.org/10.1016/j.tca.2019.178346
http://hdl.handle.net/11449/198125
Access Level:acceso abierto
Palabra clave:Ciprofloxacin
Cocrystal
Mechanochemical synthesis
Solubility study
Thermal analysis
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spelling Cocrystals of ciprofloxacin with nicotinic and isonicotinic acids: Mechanochemical synthesis, characterization, thermal and solubility studyCiprofloxacinCocrystalMechanochemical synthesisSolubility studyThermal analysisThis article describes the synthesis and characterization of new cocrystals of ciprofloxacin with nicotinic and isonicotinic acids as coformers. The cocrystals were obtained by a mechanochemical method (neat and liquid-assisted grinding). The characterization of the cocrystals was carried out using differential scanning calorimetry (DSC), thermogravimetry and simultaneous differential thermal analysis (TG-DTA), infrared spectroscopy (IR), and powder X-ray diffractometry (PXRD). Using these thermal, spectroscopic and diffractometric methods it was possible to verify the formation of the cocrystals, either with or without the addition of ethanol. Additionally, binary phase diagrams, constructed from the data of the DSC curves, confirmed the formation of the cocrystals and their stoichiometry; 1:1 (mol/mol) was determined as the optimal stoichiometric ratio. Furthermore, the formed cocrystals were capable of improving the aqueous solubility of the bioactive agent used in this study.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Institute of Chemistry São Paulo State University (UNESP)School of Sciences São Paulo State University (UNESP)School of Pharmaceutical Sciences São Paulo State University (UNESP)Institute of Chemistry São Paulo State University (UNESP)School of Sciences São Paulo State University (UNESP)School of Pharmaceutical Sciences São Paulo State University (UNESP)Universidade Estadual Paulista (Unesp)2020-12-12T00:59:53Z2020-12-12T00:59:53Z2020-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.tca.2019.178346Thermochimica Acta, v. 685.0040-6031http://hdl.handle.net/11449/19812510.1016/j.tca.2019.1783462-s2.0-85074834942Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengThermochimica Actainfo:eu-repo/semantics/openAccessde Almeida, Amanda Cosmo [UNESP]Torquetti, Carolina [UNESP]Ferreira, Patrícia Osório [UNESP]Fernandes, Richard Perosa [UNESP]dos Santos, Everton Carvalho [UNESP]Kogawa, Ana Carolina [UNESP]Caires, Flávio Junior [UNESP]2025-06-24T06:38:39Zoai:repositorio.unesp.br:11449/198125Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-06-24T06:38:39Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cocrystals of ciprofloxacin with nicotinic and isonicotinic acids: Mechanochemical synthesis, characterization, thermal and solubility study
title Cocrystals of ciprofloxacin with nicotinic and isonicotinic acids: Mechanochemical synthesis, characterization, thermal and solubility study
spellingShingle Cocrystals of ciprofloxacin with nicotinic and isonicotinic acids: Mechanochemical synthesis, characterization, thermal and solubility study
de Almeida, Amanda Cosmo [UNESP]
Ciprofloxacin
Cocrystal
Mechanochemical synthesis
Solubility study
Thermal analysis
title_short Cocrystals of ciprofloxacin with nicotinic and isonicotinic acids: Mechanochemical synthesis, characterization, thermal and solubility study
title_full Cocrystals of ciprofloxacin with nicotinic and isonicotinic acids: Mechanochemical synthesis, characterization, thermal and solubility study
title_fullStr Cocrystals of ciprofloxacin with nicotinic and isonicotinic acids: Mechanochemical synthesis, characterization, thermal and solubility study
title_full_unstemmed Cocrystals of ciprofloxacin with nicotinic and isonicotinic acids: Mechanochemical synthesis, characterization, thermal and solubility study
title_sort Cocrystals of ciprofloxacin with nicotinic and isonicotinic acids: Mechanochemical synthesis, characterization, thermal and solubility study
dc.creator.none.fl_str_mv de Almeida, Amanda Cosmo [UNESP]
Torquetti, Carolina [UNESP]
Ferreira, Patrícia Osório [UNESP]
Fernandes, Richard Perosa [UNESP]
dos Santos, Everton Carvalho [UNESP]
Kogawa, Ana Carolina [UNESP]
Caires, Flávio Junior [UNESP]
author de Almeida, Amanda Cosmo [UNESP]
author_facet de Almeida, Amanda Cosmo [UNESP]
Torquetti, Carolina [UNESP]
Ferreira, Patrícia Osório [UNESP]
Fernandes, Richard Perosa [UNESP]
dos Santos, Everton Carvalho [UNESP]
Kogawa, Ana Carolina [UNESP]
Caires, Flávio Junior [UNESP]
author_role author
author2 Torquetti, Carolina [UNESP]
Ferreira, Patrícia Osório [UNESP]
Fernandes, Richard Perosa [UNESP]
dos Santos, Everton Carvalho [UNESP]
Kogawa, Ana Carolina [UNESP]
Caires, Flávio Junior [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.subject.por.fl_str_mv Ciprofloxacin
Cocrystal
Mechanochemical synthesis
Solubility study
Thermal analysis
topic Ciprofloxacin
Cocrystal
Mechanochemical synthesis
Solubility study
Thermal analysis
description This article describes the synthesis and characterization of new cocrystals of ciprofloxacin with nicotinic and isonicotinic acids as coformers. The cocrystals were obtained by a mechanochemical method (neat and liquid-assisted grinding). The characterization of the cocrystals was carried out using differential scanning calorimetry (DSC), thermogravimetry and simultaneous differential thermal analysis (TG-DTA), infrared spectroscopy (IR), and powder X-ray diffractometry (PXRD). Using these thermal, spectroscopic and diffractometric methods it was possible to verify the formation of the cocrystals, either with or without the addition of ethanol. Additionally, binary phase diagrams, constructed from the data of the DSC curves, confirmed the formation of the cocrystals and their stoichiometry; 1:1 (mol/mol) was determined as the optimal stoichiometric ratio. Furthermore, the formed cocrystals were capable of improving the aqueous solubility of the bioactive agent used in this study.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T00:59:53Z
2020-12-12T00:59:53Z
2020-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.tca.2019.178346
Thermochimica Acta, v. 685.
0040-6031
http://hdl.handle.net/11449/198125
10.1016/j.tca.2019.178346
2-s2.0-85074834942
url http://dx.doi.org/10.1016/j.tca.2019.178346
http://hdl.handle.net/11449/198125
identifier_str_mv Thermochimica Acta, v. 685.
0040-6031
10.1016/j.tca.2019.178346
2-s2.0-85074834942
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Thermochimica Acta
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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score 15.300719

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