Adverse events following immunization in Brazil : age of child and vaccine-associated risk analysis using logistic regression
Objective: Vaccines are effective in controlling and eradicating infectious diseases. However, adverse events following immunization (AEFI) can occur in susceptible individuals. The objective of this study was to analyze the Brazilian AEFI database and compare eight vaccines in order to profile risk...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | Brasil |
| Institución: | Universidade Federal do Rio Grande do Sul (UFRGS) |
| Repositorio: | Repositório Institucional da UFRGS |
| Idioma: | inglés |
| OAI Identifier: | oai:www.lume.ufrgs.br:10183/184135 |
| Acceso en línea: | http://hdl.handle.net/10183/184135 |
| Access Level: | acceso abierto |
| Palabra clave: | Vacinas Efeitos colaterais e reações adversas relacionados a medicamentos Imunização Vigilância em saúde pública Estatística médica Brasil Vaccine Adverse event Immunization AEFI Passive surveillance |
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2018-10-27T03:12:53Z20181660-4601http://hdl.handle.net/10183/184135001073239Objective: Vaccines are effective in controlling and eradicating infectious diseases. However, adverse events following immunization (AEFI) can occur in susceptible individuals. The objective of this study was to analyze the Brazilian AEFI database and compare eight vaccines in order to profile risks of AEFIs related to the mandated pediatric schedule of immunization, considering the age and sex of the child, type of vaccine, and reported adverse events. Methods: We analyzed the Brazilian AEFI database integrating reports between 2005 and 2010 for children less than 10-years old immunized with eight mandated vaccines: diphtheria, pertussis, tetanus, Haemophilus influenzae type b (TETRA); diphtheria, tetanus, and pertussis (DTP); Bacillus Calmette–Guerin (BCG); oral poliovirus vaccine (OPV); measles, mumps, and rubella (MMR); oral rotavirus vaccine (ORV); hepatitis B (HB); and yellow fever (YF). We compared the children’s age regarding types of AEFI, evaluated AEFI factors associated with the chance of hospitalization of the child, and estimated the chance of notification of an AEFI as a function of the type of vaccine. In total, 47,105 AEFIs were observed for the mandated vaccines. Results: The highest AEFI rate was for the TETRA vaccine and the lowest was for the OPV vaccine, with 60.1 and 2.3 events per 100,000 inoculations, respectively. The TETRA vaccine showed the highest rate of hypotonic hyporesponsive episode, followed by convulsion and fever. The MMR and YF vaccines were associated with generalized rash. BCG was associated with enlarged lymph glands but showed the largest negative (protective) association with hyporesponsive events and seizures. Compared with children aged 5–9-years old, young children (<1 year) showed significantly higher odds of hospitalization. Conclusions: The Brazilian AEFI registry is useful to compare the magnitude and certain characteristics of adverse events associated with mandated pediatric vaccines.application/pdfengInternational journal of environmental research and public health. Basel. Vol. 15, no. 6 (June 2018), 1149, 13 p.VacinasEfeitos colaterais e reações adversas relacionados a medicamentosImunizaçãoVigilância em saúde públicaEstatística médicaBrasilVaccineAdverse eventImmunizationAEFIPassive surveillanceAdverse events following immunization in Brazil : age of child and vaccine-associated risk analysis using logistic regressionEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSLopes, Silvia Regina CostaPerin, João Lucas da RosaPrass, Taiane SchaedlerCarvalho, Sandra Maria DeottiLessa, Sérgio de CastroDorea, Jose GarrofeORIGINAL001073239.pdfTexto completo (inglês)application/pdf506742http://www.lume.ufrgs.br/bitstream/10183/184135/1/001073239.pdf51226a3b294d0933df4b56d2fe59bb17MD51TEXT001073239.pdf.txt001073239.pdf.txtExtracted Texttext/plain50764http://www.lume.ufrgs.br/bitstream/10183/184135/2/001073239.pdf.txt1218dfca80180f657d3ee1a3a73e3a0aMD52THUMBNAIL001073239.pdf.jpg001073239.pdf.jpgGenerated Thumbnailimage/jpeg1866http://www.lume.ufrgs.br/bitstream/10183/184135/3/001073239.pdf.jpg85ace63eff67a913cce6f8cc5ab6552aMD5310183/1841352018-10-29 07:32:21.367oai:www.lume.ufrgs.br:10183/184135Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2018-10-29T10:32:21Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
| dc.title.pt_BR.fl_str_mv |
Adverse events following immunization in Brazil : age of child and vaccine-associated risk analysis using logistic regression |
| title |
Adverse events following immunization in Brazil : age of child and vaccine-associated risk analysis using logistic regression |
| spellingShingle |
Adverse events following immunization in Brazil : age of child and vaccine-associated risk analysis using logistic regression Lopes, Silvia Regina Costa Vacinas Efeitos colaterais e reações adversas relacionados a medicamentos Imunização Vigilância em saúde pública Estatística médica Brasil Vaccine Adverse event Immunization AEFI Passive surveillance |
| title_short |
Adverse events following immunization in Brazil : age of child and vaccine-associated risk analysis using logistic regression |
| title_full |
Adverse events following immunization in Brazil : age of child and vaccine-associated risk analysis using logistic regression |
| title_fullStr |
Adverse events following immunization in Brazil : age of child and vaccine-associated risk analysis using logistic regression |
| title_full_unstemmed |
Adverse events following immunization in Brazil : age of child and vaccine-associated risk analysis using logistic regression |
| title_sort |
Adverse events following immunization in Brazil : age of child and vaccine-associated risk analysis using logistic regression |
| dc.creator.none.fl_str_mv |
Lopes, Silvia Regina Costa Perin, João Lucas da Rosa Prass, Taiane Schaedler Carvalho, Sandra Maria Deotti Lessa, Sérgio de Castro Dorea, Jose Garrofe |
| author |
Lopes, Silvia Regina Costa |
| author_facet |
Lopes, Silvia Regina Costa Perin, João Lucas da Rosa Prass, Taiane Schaedler Carvalho, Sandra Maria Deotti Lessa, Sérgio de Castro Dorea, Jose Garrofe |
| author_role |
author |
| author2 |
Perin, João Lucas da Rosa Prass, Taiane Schaedler Carvalho, Sandra Maria Deotti Lessa, Sérgio de Castro Dorea, Jose Garrofe |
| author2_role |
author author author author author |
| dc.subject.por.fl_str_mv |
Vacinas Efeitos colaterais e reações adversas relacionados a medicamentos Imunização Vigilância em saúde pública Estatística médica Brasil |
| topic |
Vacinas Efeitos colaterais e reações adversas relacionados a medicamentos Imunização Vigilância em saúde pública Estatística médica Brasil Vaccine Adverse event Immunization AEFI Passive surveillance |
| dc.subject.eng.fl_str_mv |
Vaccine Adverse event Immunization AEFI Passive surveillance |
| description |
Objective: Vaccines are effective in controlling and eradicating infectious diseases. However, adverse events following immunization (AEFI) can occur in susceptible individuals. The objective of this study was to analyze the Brazilian AEFI database and compare eight vaccines in order to profile risks of AEFIs related to the mandated pediatric schedule of immunization, considering the age and sex of the child, type of vaccine, and reported adverse events. Methods: We analyzed the Brazilian AEFI database integrating reports between 2005 and 2010 for children less than 10-years old immunized with eight mandated vaccines: diphtheria, pertussis, tetanus, Haemophilus influenzae type b (TETRA); diphtheria, tetanus, and pertussis (DTP); Bacillus Calmette–Guerin (BCG); oral poliovirus vaccine (OPV); measles, mumps, and rubella (MMR); oral rotavirus vaccine (ORV); hepatitis B (HB); and yellow fever (YF). We compared the children’s age regarding types of AEFI, evaluated AEFI factors associated with the chance of hospitalization of the child, and estimated the chance of notification of an AEFI as a function of the type of vaccine. In total, 47,105 AEFIs were observed for the mandated vaccines. Results: The highest AEFI rate was for the TETRA vaccine and the lowest was for the OPV vaccine, with 60.1 and 2.3 events per 100,000 inoculations, respectively. The TETRA vaccine showed the highest rate of hypotonic hyporesponsive episode, followed by convulsion and fever. The MMR and YF vaccines were associated with generalized rash. BCG was associated with enlarged lymph glands but showed the largest negative (protective) association with hyporesponsive events and seizures. Compared with children aged 5–9-years old, young children (<1 year) showed significantly higher odds of hospitalization. Conclusions: The Brazilian AEFI registry is useful to compare the magnitude and certain characteristics of adverse events associated with mandated pediatric vaccines. |
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2018 |
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2018-10-27T03:12:53Z |
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2018 |
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Estrangeiro info:eu-repo/semantics/article |
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International journal of environmental research and public health. Basel. Vol. 15, no. 6 (June 2018), 1149, 13 p. |
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