Protein secretion in Pichia pastoris and advances in protein production. Applied Microbiology Biotechnology

Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil

Detalles Bibliográficos
Autores: Damasceno, Leonardo Miranda, Huang, C. J., Batt, C. A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:Brasil
Institución:Fundação Oswaldo Cruz (FIOCRUZ)
Repositorio:Repositório Institucional da FIOCRUZ (ARCA)
Idioma:inglés
OAI Identifier:oai:arca.fiocruz.br:icict/7427
Acceso en línea:https://arca.fiocruz.br/handle/icict/7427
Access Level:acceso abierto
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dc.title.none.fl_str_mv Protein secretion in Pichia pastoris and advances in protein production. Applied Microbiology Biotechnology
title Protein secretion in Pichia pastoris and advances in protein production. Applied Microbiology Biotechnology
spellingShingle Protein secretion in Pichia pastoris and advances in protein production. Applied Microbiology Biotechnology
Damasceno, Leonardo Miranda
title_short Protein secretion in Pichia pastoris and advances in protein production. Applied Microbiology Biotechnology
title_full Protein secretion in Pichia pastoris and advances in protein production. Applied Microbiology Biotechnology
title_fullStr Protein secretion in Pichia pastoris and advances in protein production. Applied Microbiology Biotechnology
title_full_unstemmed Protein secretion in Pichia pastoris and advances in protein production. Applied Microbiology Biotechnology
title_sort Protein secretion in Pichia pastoris and advances in protein production. Applied Microbiology Biotechnology
dc.creator.none.fl_str_mv Damasceno, Leonardo Miranda
Huang, C. J.
Batt, C. A.
author Damasceno, Leonardo Miranda
author_facet Damasceno, Leonardo Miranda
Huang, C. J.
Batt, C. A.
author_role author
author2 Huang, C. J.
Batt, C. A.
author2_role author
author
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-03-19T18:13:59Z
dc.date.available.fl_str_mv 2014-03-19T18:13:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv DAMASCENO, Leonardo Miranda; HUANG, CJ; BATT, CA. Protein secretion in Pichia pastoris and advances in protein production. Applied Microbiology Biotechnology. 2012, vol.93, n.1, pp. 31-39.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/7427
dc.identifier.issn.none.fl_str_mv 0175-7598
dc.identifier.doi.none.fl_str_mv 10.1007/s00253-011-3654-z
identifier_str_mv DAMASCENO, Leonardo Miranda; HUANG, CJ; BATT, CA. Protein secretion in Pichia pastoris and advances in protein production. Applied Microbiology Biotechnology. 2012, vol.93, n.1, pp. 31-39.
0175-7598
10.1007/s00253-011-3654-z
url https://arca.fiocruz.br/handle/icict/7427
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Springer Link
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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spelling 2014-03-19T18:13:59Z2014-03-19T18:13:59Z2012DAMASCENO, Leonardo Miranda; HUANG, CJ; BATT, CA. Protein secretion in Pichia pastoris and advances in protein production. Applied Microbiology Biotechnology. 2012, vol.93, n.1, pp. 31-39.0175-7598https://arca.fiocruz.br/handle/icict/742710.1007/s00253-011-3654-zengSpringer LinkProtein secretion in Pichia pastoris and advances in protein production. Applied Microbiology Biotechnologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilCornell University. Department of Microbiolog. Ithaca, NY, USACornell University. Department of Microbiolog. Ithaca, NY, USAYeast expression systems have been successfully used for over 20 years for the production of recombinant proteins. With the growing interest in recombinant protein expression for various uses, yeast expression systems, such as the popular Pichia pastoris, are becoming increasingly important. Although P. pastoris has been successfully used in the production of many secreted and intracellular recombinant proteins, there is still room for improvement of this expression system. In particular, secretion of recombinant proteins is still one of the main reasons for using P. pastoris. Therefore, endoplasmic reticulum protein folding, correct glycosylation, vesicular transport to the plasma membrane, gene dosage, secretion signal sequences, and secretome studies are important considerations for improved recombinant protein production.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZDamasceno, Leonardo MirandaHuang, C. J.Batt, C. 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