The effects of fibroblast growth factor-23 on diagnosis of cerebral infarction and vertebral basilar artery stenosis

Objectives: This study aimed to explore the correlation between Fibroblast Growth Factor-23 (FGF23) levels and Cerebral Infarction (CI), and to determine whether there is a significant relationship between FGF23 and the occurrence and severity of CI. Methods: The study categorized Cerebral Infarctio...

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Detalles Bibliográficos
Autores: Wei, Zhuoqun, Zhong, Changyang, Wu, Chunli, Liu, Yuan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:Brasil
Institución:Universidade de São Paulo (USP)
Repositorio:Clinics
Idioma:inglés
OAI Identifier:oai:revistas.usp.br:article/237519
Acceso en línea:https://revistas.usp.br/clinics/article/view/237519
Access Level:acceso abierto
Palabra clave:Fibroblast growth factor-23
Cerebral infarction
DSA
Stents
Vertebrobasilar artery stenosis
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spelling The effects of fibroblast growth factor-23 on diagnosis of cerebral infarction and vertebral basilar artery stenosisFibroblast growth factor-23Cerebral infarctionDSAStentsVertebrobasilar artery stenosisObjectives: This study aimed to explore the correlation between Fibroblast Growth Factor-23 (FGF23) levels and Cerebral Infarction (CI), and to determine whether there is a significant relationship between FGF23 and the occurrence and severity of CI. Methods: The study categorized Cerebral Infarction (CI) patients into severe and mild stenosis groups based on vertebrobasilar artery stenosis, using Digital Subtraction Angiography (DSA) and Magnetic Resonance Imaging (MRI). The study compared the levels of Fibroblast Growth Factor-23 (FGF23) in the serum of CI patients and healthy controls using a t-test and evaluated the diagnostic effectiveness of serum FGF23 using a Receiver Operating Characteristic (ROC) curve. Additionally, the study analyzed the correlation between FGF23 levels and CI severity after treatment using the National Institute of Health Stroke Scale score. Results: The study found a significant increase in serum Fibroblast Growth Factor-23 (FGF23) levels in patients with Cerebral Infarction (CI) compared to healthy volunteers, (p < 0.001). A higher serum FGF23 level was observed in the severe stenosis group than in the mild stenosis group (p < 0.001). Furthermore, the study showed that a high FGF23 level at admission was significantly related to more severe symptoms of CI as indicated by the National Institute of Health Stroke Scale (NIHSS) score on the 7th day after treatment (p < 0.001) Conclusions: This study discovered a correlation between Fibroblast Growth Factor-23 (FGF23) levels, vertebrobasilar artery stenosis, and short-term prognosis in patients who had recently experienced acute Cerebral Infarction (CI).Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2024-02-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistas.usp.br/clinics/article/view/23751910.1016/Clinics; Vol. 79 (2024); 100457Clinics; v. 79 (2024); 100457Clinics; Vol. 79 (2024); 1004571980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://revistas.usp.br/clinics/article/view/237519/214410Copyright (c) 2024 Clinicsinfo:eu-repo/semantics/openAccessWei, ZhuoqunZhong, ChangyangWu, ChunliLiu, Yuan2025-06-17T18:45:43Zoai:revistas.usp.br:article/237519Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2025-06-17T18:45:43Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv The effects of fibroblast growth factor-23 on diagnosis of cerebral infarction and vertebral basilar artery stenosis
title The effects of fibroblast growth factor-23 on diagnosis of cerebral infarction and vertebral basilar artery stenosis
spellingShingle The effects of fibroblast growth factor-23 on diagnosis of cerebral infarction and vertebral basilar artery stenosis
Wei, Zhuoqun
Fibroblast growth factor-23
Cerebral infarction
DSA
Stents
Vertebrobasilar artery stenosis
title_short The effects of fibroblast growth factor-23 on diagnosis of cerebral infarction and vertebral basilar artery stenosis
title_full The effects of fibroblast growth factor-23 on diagnosis of cerebral infarction and vertebral basilar artery stenosis
title_fullStr The effects of fibroblast growth factor-23 on diagnosis of cerebral infarction and vertebral basilar artery stenosis
title_full_unstemmed The effects of fibroblast growth factor-23 on diagnosis of cerebral infarction and vertebral basilar artery stenosis
title_sort The effects of fibroblast growth factor-23 on diagnosis of cerebral infarction and vertebral basilar artery stenosis
dc.creator.none.fl_str_mv Wei, Zhuoqun
Zhong, Changyang
Wu, Chunli
Liu, Yuan
author Wei, Zhuoqun
author_facet Wei, Zhuoqun
Zhong, Changyang
Wu, Chunli
Liu, Yuan
author_role author
author2 Zhong, Changyang
Wu, Chunli
Liu, Yuan
author2_role author
author
author
dc.subject.por.fl_str_mv Fibroblast growth factor-23
Cerebral infarction
DSA
Stents
Vertebrobasilar artery stenosis
topic Fibroblast growth factor-23
Cerebral infarction
DSA
Stents
Vertebrobasilar artery stenosis
description Objectives: This study aimed to explore the correlation between Fibroblast Growth Factor-23 (FGF23) levels and Cerebral Infarction (CI), and to determine whether there is a significant relationship between FGF23 and the occurrence and severity of CI. Methods: The study categorized Cerebral Infarction (CI) patients into severe and mild stenosis groups based on vertebrobasilar artery stenosis, using Digital Subtraction Angiography (DSA) and Magnetic Resonance Imaging (MRI). The study compared the levels of Fibroblast Growth Factor-23 (FGF23) in the serum of CI patients and healthy controls using a t-test and evaluated the diagnostic effectiveness of serum FGF23 using a Receiver Operating Characteristic (ROC) curve. Additionally, the study analyzed the correlation between FGF23 levels and CI severity after treatment using the National Institute of Health Stroke Scale score. Results: The study found a significant increase in serum Fibroblast Growth Factor-23 (FGF23) levels in patients with Cerebral Infarction (CI) compared to healthy volunteers, (p < 0.001). A higher serum FGF23 level was observed in the severe stenosis group than in the mild stenosis group (p < 0.001). Furthermore, the study showed that a high FGF23 level at admission was significantly related to more severe symptoms of CI as indicated by the National Institute of Health Stroke Scale (NIHSS) score on the 7th day after treatment (p < 0.001) Conclusions: This study discovered a correlation between Fibroblast Growth Factor-23 (FGF23) levels, vertebrobasilar artery stenosis, and short-term prognosis in patients who had recently experienced acute Cerebral Infarction (CI).
publishDate 2024
dc.date.none.fl_str_mv 2024-02-15
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistas.usp.br/clinics/article/view/237519
10.1016/
url https://revistas.usp.br/clinics/article/view/237519
identifier_str_mv 10.1016/
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revistas.usp.br/clinics/article/view/237519/214410
dc.rights.driver.fl_str_mv Copyright (c) 2024 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2024 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 79 (2024); 100457
Clinics; v. 79 (2024); 100457
Clinics; Vol. 79 (2024); 100457
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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score 15,198674

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