Catalyzed and non-catalyzed synthesis of bioactive monastrol

The bioactive 3,4-dihydropyrimidin-2(1H)-thione derivative known as Monastrol was synthesized under catalyzed and non-catalyzed conditions through the Biginelli multicomponent reaction under solvent-free conditions. The use of two Lewis acids (FeCl3 and CuCl2) and two Brønsted acids (HCl and CF3COOH...

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Detalhes bibliográficos
Autores: Alvim, Haline Gerica de Oliveira, Corrêa, José Raimundo, Machado, Taynara Rezende, Silva, Wender Alves da, Neto, Brenno A.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:Brasil
Recursos:Universidade de Brasília (UnB)
Repositorio:Repositório Institucional da UnB
Idioma:inglés
OAI Identifier:oai:repositorio.unb.br:10482/29152
Acesso em linha:http://repositorio.unb.br/handle/10482/29152
https://dx.doi.org/10.5935/0100-4042.20140266
Access Level:acceso abierto
Palavra-chave:Monastrol
Reação de Biginelli
Catálise
Descrição
Resumo:The bioactive 3,4-dihydropyrimidin-2(1H)-thione derivative known as Monastrol was synthesized under catalyzed and non-catalyzed conditions through the Biginelli multicomponent reaction under solvent-free conditions. The use of two Lewis acids (FeCl3 and CuCl2) and two Brønsted acids (HCl and CF3COOH) as catalysts improved the reaction yields of the transformation compared with the non-catalyzed reaction. The experiments investigated catalysis and its role, the importance of multicomponent reactions and their green features, and the application of these concepts to the synthesis of a biologically important structure.