Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car?
Ambrisentan in 22 patients with pulmonary hypertension diagnosed during exercise (ePH) improved pulmonary hemodynamics; however, there was only a trend toward increased maximum oxygen uptake (VO(2)max) secondary to decreased maximum exercise systemic oxygen extraction (Ca-vO(2)). We speculate that i...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | Brasil |
| Institución: | Universidade Federal de São Paulo (UNIFESP) |
| Repositorio: | Repositório Institucional da UNIFESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unifesp.br:11600/54252 |
| Acceso en línea: | http://dx.doi.org/10.1177/2045893218755325 https://repositorio.unifesp.br/handle/11600/54252 |
| Access Level: | acceso abierto |
| Palabra clave: | systemic oxygen extraction pulmonary hypertension ambrisentan exercise |
| Sumario: | Ambrisentan in 22 patients with pulmonary hypertension diagnosed during exercise (ePH) improved pulmonary hemodynamics; however, there was only a trend toward increased maximum oxygen uptake (VO(2)max) secondary to decreased maximum exercise systemic oxygen extraction (Ca-vO(2)). We speculate that improved pulmonary hemodynamics at maximum exercise "unmasked" a pre-existing skeletal muscle abnormality. |
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