Esquizofrenia : quarenta anos da hipótese dopaminérgica sob a ótica da química medicinal
Schizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and continues as a challenge to neuroscience. In this work, we describe an account about the historical evolution of the dopaminergic hypothesis of schizophrenia discussing, from the medicinal chemistry poin...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2004 |
| País: | Brasil |
| Institución: | Universidade Federal do Rio Grande do Sul (UFRGS) |
| Repositorio: | Repositório Institucional da UFRGS |
| Idioma: | portugués |
| OAI Identifier: | oai:www.lume.ufrgs.br:10183/72986 |
| Acceso en línea: | http://hdl.handle.net/10183/72986 |
| Access Level: | acceso abierto |
| Palabra clave: | Esquizofrenia Antipsicóticos Receptores dopaminérgicos Schizophrenia Antipsychotic drugs Dopamine receptor ligands |
| Sumario: | Schizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and continues as a challenge to neuroscience. In this work, we describe an account about the historical evolution of the dopaminergic hypothesis of schizophrenia discussing, from the medicinal chemistry point of view all different classes of antipsychotic drugs, emphasizing the rational design, structure activity relationships (SAR) and physico-chemical properties related with its molecular mechanism of action. |
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