Chronic pulmonary aspergillosis due to Aspergillus nomius in a patient with disseminated phaeohyphomycosis resistant to antifungal drugs
The aim of this presentation is to present the clinical, mycological and histopathological findings of a case of chronic pulmonary aspergillosis due to Aspergillus nomius, in a 52 year old woman, who suffers from disseminated phaeohyphomycosis with cutaneous, ganglionary and bone lesions due to Exop...
| Autores: | , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2012 |
| País: | Brasil |
| Institución: | Universidade Federal de Goiás (UFG) |
| Repositorio: | Revista de patologia tropical (Online) |
| Idioma: | portugués |
| OAI Identifier: | oai:ojs.revistas.ufg.br:article/21713 |
| Acceso en línea: | https://revistas.ufg.br/iptsp/article/view/21713 |
| Access Level: | acceso abierto |
| Palabra clave: | Aspergillus nomius chronic pulmonary aspergillosis phaeohyphomycosis Exophiala spinifera posaconazole caspofungin. Aspergilosis pulmonar Feohifomicosis Caspofungina Posaconazol. |
| Sumario: | The aim of this presentation is to present the clinical, mycological and histopathological findings of a case of chronic pulmonary aspergillosis due to Aspergillus nomius, in a 52 year old woman, who suffers from disseminated phaeohyphomycosis with cutaneous, ganglionary and bone lesions due to Exophiala spinifera with 22 years of evolution. This pulmonary aspergillosis presented clinicallyas a chronic pneumonia of the middle lobe of the right lung, which evolved toward excavation and the production of a chronic lung abscess. This mycosis appeared during posaconazole treatment, at a daily dose of 800 mg, and the infection presented a good clinical response to intravenous caspofungin. The patient was submitted to surgical remotion of middle and lower lobes of the right lung. Histopathological study of the surgical sample showed Aspergillus nomius invasion of blood vessels and the production of an epithelioid granuloma with giant cells around the endovascular hyphae. The etiologic agent of this aspergillosis was also isolated from several sputum and bronchoalveolar lavage samples and its identification as Aspergillus nomius was done by molecular biology studies. We were not able to establish a clear cause of immunodeficiency. |
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