Quality Analysis of Different Brands of Captopril Table

Quality control consists of a set of operations in order to verify if the product conforms to the specifications of the pharmacopoeia, to assure its safety, its therapeutic efficacy and its quality, throughout the validity period. For the patient, the lack of quality of the product causes serious tr...

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Authors: Domiciano, Samyra Leandro, Farias, Sandra Ramos, Jordão, Christiane Oliveira
Format: article
Status:Published version
Publication Date:2014
Country:Brasil
Institution:Universidade de Araraquara (UNIARA)
Repository:Revista Brasileira Multidisciplinar
Language:Portuguese
OAI Identifier:oai:ojs.revistarebram.com:article/31
Online Access:http://revistarebram.com/index.php/revistauniara/article/view/31
Access Level:Open access
Keyword:Quality Control
Analysis
Captopril.
Controle de qualidade
Análise
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spelling Quality Analysis of Different Brands of Captopril TableAnálise de Qualidade de Diferentes Marcas de Comprimidos de CaptoprilQuality ControlAnalysisCaptopril.Controle de qualidadeAnáliseCaptopril.Quality control consists of a set of operations in order to verify if the product conforms to the specifications of the pharmacopoeia, to assure its safety, its therapeutic efficacy and its quality, throughout the validity period. For the patient, the lack of quality of the product causes serious trouble with health risks. The annual consumption of antihypertensive drugs rose from January 2010 to April 2013, an increase of 41.1 million to 119 million units, with 16.57% share of sales attributable to drugs to control blood pressure in which captopril represents 1.47%. Considering these data, the present study aimed at quantifying the content of captopril tablets of different brands available in the pharmaceutical market. Analyses were performed with 25 mg tablets of six different laboratories, being three similar and three generic ones. The analysis methodology was based on titrimetric method, determining the individual and mean weight of the tablets analyzed, as shown in the official methodology. Duplicate analyzes were performed. The data were statistically evaluated by determining the coefficient of variation and standard deviation. Despite the analyzed brands present statistical differences, it is possible to confirm that the tests of all samples were within the established standards.O controle de qualidade consiste em um conjunto de operações com o objetivo de verificar se o produto está em conformidade com as especificações da farmacopeia, que garantem a segurança, eficácia terapêutica e a qualidade deste, durante todo o prazo da validade. Para o paciente, a falta de qualidade do medicamento ocasiona sérios transtornos com o comprometimento da sua saúde. O consumo anual dos anti-hipertensivos subiu no período de janeiro de 2010 a abril de 2013, apresentando um aumento de 41,1 milhões para 119 milhões de unidades, com 16,57% de participação nas vendas atribuídas aos medicamentos para controle da pressão arterial, em que o captopril representa 1,47% destas. Diante desses dados, o presente trabalho propôs a quantificação do teor de comprimidos de captopril de diferentes marcas disponíveis no mercado farmacêutico. Foram realizadas análises com os comprimidos de 25 mg de seis laboratórios diferentes, sendo três genéricos e três similares. A metodologia de análise baseou-se em método titulométrico, determinação do peso individual e médio dos comprimidos analisados, conforme apresentado na metodologia oficial. As análises foram feitas em duplicata. Os dados obtidos foram estatisticamente avaliados determinando o coeficiente de variação e desvio padrão. Apesar das marcas analisadas apresentarem diferenças estatísticas, pode-se afirmar que, dentre os testes realizados, todas as amostras estavam dentro dos padrões estabelecidos.Revista Brasileira Multidisciplinar - ReBraM2014-07-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://revistarebram.com/index.php/revistauniara/article/view/3110.25061/2527-2675/ReBraM/2014.v17i2.31Revista Brasileira Multidisciplinar - ReBraM; v. 17 n. 2 (2014): Julho/dezembro; 107-1152527-26751415-3580reponame:Revista Brasileira Multidisciplinarinstname:Universidade de Araraquara (UNIARA)instacron:UNIARAporhttp://revistarebram.com/index.php/revistauniara/article/view/31/21info:eu-repo/semantics/openAccessDomiciano, Samyra LeandroFarias, Sandra RamosJordão, Christiane Oliveira2018-03-08T14:23:38Zoai:ojs.revistarebram.com:article/31Revistahttp://revistarebram.com/index.php/revistauniaraPRIhttps://revistarebram.com/index.php/revistauniara/oairevistauniara@uniara.com||2527-26752527-2675opendoar:2018-03-08T14:23:38Revista Brasileira Multidisciplinar - Universidade de Araraquara (UNIARA)false
dc.title.none.fl_str_mv Quality Analysis of Different Brands of Captopril Table
Análise de Qualidade de Diferentes Marcas de Comprimidos de Captopril
title Quality Analysis of Different Brands of Captopril Table
spellingShingle Quality Analysis of Different Brands of Captopril Table
Domiciano, Samyra Leandro
Quality Control
Analysis
Captopril.
Controle de qualidade
Análise
Captopril.
title_short Quality Analysis of Different Brands of Captopril Table
title_full Quality Analysis of Different Brands of Captopril Table
title_fullStr Quality Analysis of Different Brands of Captopril Table
title_full_unstemmed Quality Analysis of Different Brands of Captopril Table
title_sort Quality Analysis of Different Brands of Captopril Table
dc.creator.none.fl_str_mv Domiciano, Samyra Leandro
Farias, Sandra Ramos
Jordão, Christiane Oliveira
author Domiciano, Samyra Leandro
author_facet Domiciano, Samyra Leandro
Farias, Sandra Ramos
Jordão, Christiane Oliveira
author_role author
author2 Farias, Sandra Ramos
Jordão, Christiane Oliveira
author2_role author
author
dc.subject.por.fl_str_mv Quality Control
Analysis
Captopril.
Controle de qualidade
Análise
Captopril.
topic Quality Control
Analysis
Captopril.
Controle de qualidade
Análise
Captopril.
description Quality control consists of a set of operations in order to verify if the product conforms to the specifications of the pharmacopoeia, to assure its safety, its therapeutic efficacy and its quality, throughout the validity period. For the patient, the lack of quality of the product causes serious trouble with health risks. The annual consumption of antihypertensive drugs rose from January 2010 to April 2013, an increase of 41.1 million to 119 million units, with 16.57% share of sales attributable to drugs to control blood pressure in which captopril represents 1.47%. Considering these data, the present study aimed at quantifying the content of captopril tablets of different brands available in the pharmaceutical market. Analyses were performed with 25 mg tablets of six different laboratories, being three similar and three generic ones. The analysis methodology was based on titrimetric method, determining the individual and mean weight of the tablets analyzed, as shown in the official methodology. Duplicate analyzes were performed. The data were statistically evaluated by determining the coefficient of variation and standard deviation. Despite the analyzed brands present statistical differences, it is possible to confirm that the tests of all samples were within the established standards.
publishDate 2014
dc.date.none.fl_str_mv 2014-07-10
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://revistarebram.com/index.php/revistauniara/article/view/31
10.25061/2527-2675/ReBraM/2014.v17i2.31
url http://revistarebram.com/index.php/revistauniara/article/view/31
identifier_str_mv 10.25061/2527-2675/ReBraM/2014.v17i2.31
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv http://revistarebram.com/index.php/revistauniara/article/view/31/21
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Revista Brasileira Multidisciplinar - ReBraM
publisher.none.fl_str_mv Revista Brasileira Multidisciplinar - ReBraM
dc.source.none.fl_str_mv Revista Brasileira Multidisciplinar - ReBraM; v. 17 n. 2 (2014): Julho/dezembro; 107-115
2527-2675
1415-3580
reponame:Revista Brasileira Multidisciplinar
instname:Universidade de Araraquara (UNIARA)
instacron:UNIARA
instname_str Universidade de Araraquara (UNIARA)
instacron_str UNIARA
institution UNIARA
reponame_str Revista Brasileira Multidisciplinar
collection Revista Brasileira Multidisciplinar
repository.name.fl_str_mv Revista Brasileira Multidisciplinar - Universidade de Araraquara (UNIARA)
repository.mail.fl_str_mv revistauniara@uniara.com||
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score 15,300719

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