Analysis of clinical characteristics and risk factors for mortality in human status epilepticus

Purpose: To analyse clinical data including aetiology, age, antecedents, classification and mortality in human status epilepticus (SE), and to assess prognostic factors for mortality.Methods: A prospective study was performed, including detailed analysis of clinical and laboratorial data of SE in in...

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Detalles Bibliográficos
Autores: Garzon, Eliana [UNIFESP], Fernandes, Regina Maria França, Sakamoto, Américo Ceiki [UNIFESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2003
País:Brasil
Institución:Universidade Federal de São Paulo (UNIFESP)
Repositorio:Repositório Institucional da UNIFESP
Idioma:inglés
OAI Identifier:oai:repositorio.unifesp.br:11600/27369
Acceso en línea:http://dx.doi.org/10.1016/S1059-1311(02)00324-2
http://repositorio.unifesp.br/handle/11600/27369
Access Level:acceso abierto
Palabra clave:status epilepticus
refractory status epilepticus
Epilepsy
Mortality
EEG
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spelling Analysis of clinical characteristics and risk factors for mortality in human status epilepticusstatus epilepticusrefractory status epilepticusEpilepsyMortalityEEGPurpose: To analyse clinical data including aetiology, age, antecedents, classification and mortality in human status epilepticus (SE), and to assess prognostic factors for mortality.Methods: A prospective study was performed, including detailed analysis of clinical and laboratorial data of SE in individuals of any age. except neonates.Results: One hundred and eleven SE were included, with patients' age ranging from 3 months to 98 years. SE incidence peaked in the first year of life, and 59.4% of the individuals had previous epilepsy while 40.6% had not. the main underlying causes were noncompliance to treatment in the first group, and CNS infection, stroke and metabolic disturbances in the second group. Overall mortality was 19.8%. and deaths were correlated to aetiology and patient's age. Refractory SE affected 11.7% of the cases. Clinical types included focal, secondarily generalised and generalised SE. Clinical and clinicoelectrographic classifications were convergent, but EEG was essential for the diagnosis in 4.5% of the cases.Conclusions: Epileptic patients are at greater risk to develop SE, however, individuals with no prior history of epilepsy and acute neurological problems can also present SE. Aetiology varies with patient's age, and mortality is high and related to age and underlying causes. Clinical and clinicoelectrographic classifications are usually convergent, but in some cases the diagnosis of SE would not be established without the EEG. (C) 2003 BEA Trading Ltd. Published by Elsevier B.V. All rights reserved.Universidade Federal de São Paulo, Dept Neurol & Neurosurg, São Paulo, BrazilUniv São Paulo, Ribeirao Preto Sch Med, Dept Neurol Psychiat & Psychol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, São Paulo, BrazilWeb of ScienceW B Saunders Co LtdUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)2016-01-24T12:34:00Z2016-01-24T12:34:00Z2003-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion337-345application/pdfhttp://dx.doi.org/10.1016/S1059-1311(02)00324-2Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 12, n. 6, p. 337-345, 2003.10.1016/S1059-1311(02)00324-2WOS000185039300003.pdf1059-1311http://repositorio.unifesp.br/handle/11600/27369WOS:000185039300003ark:/48912/001300002tf7pengSeizure-european Journal of Epilepsyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPGarzon, Eliana [UNIFESP]Fernandes, Regina Maria FrançaSakamoto, Américo Ceiki [UNIFESP]2024-08-07T11:29:18Zoai:repositorio.unifesp.br:11600/27369Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-07T11:29:18Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Analysis of clinical characteristics and risk factors for mortality in human status epilepticus
title Analysis of clinical characteristics and risk factors for mortality in human status epilepticus
spellingShingle Analysis of clinical characteristics and risk factors for mortality in human status epilepticus
Garzon, Eliana [UNIFESP]
status epilepticus
refractory status epilepticus
Epilepsy
Mortality
EEG
title_short Analysis of clinical characteristics and risk factors for mortality in human status epilepticus
title_full Analysis of clinical characteristics and risk factors for mortality in human status epilepticus
title_fullStr Analysis of clinical characteristics and risk factors for mortality in human status epilepticus
title_full_unstemmed Analysis of clinical characteristics and risk factors for mortality in human status epilepticus
title_sort Analysis of clinical characteristics and risk factors for mortality in human status epilepticus
dc.creator.none.fl_str_mv Garzon, Eliana [UNIFESP]
Fernandes, Regina Maria França
Sakamoto, Américo Ceiki [UNIFESP]
author Garzon, Eliana [UNIFESP]
author_facet Garzon, Eliana [UNIFESP]
Fernandes, Regina Maria França
Sakamoto, Américo Ceiki [UNIFESP]
author_role author
author2 Fernandes, Regina Maria França
Sakamoto, Américo Ceiki [UNIFESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
dc.subject.por.fl_str_mv status epilepticus
refractory status epilepticus
Epilepsy
Mortality
EEG
topic status epilepticus
refractory status epilepticus
Epilepsy
Mortality
EEG
description Purpose: To analyse clinical data including aetiology, age, antecedents, classification and mortality in human status epilepticus (SE), and to assess prognostic factors for mortality.Methods: A prospective study was performed, including detailed analysis of clinical and laboratorial data of SE in individuals of any age. except neonates.Results: One hundred and eleven SE were included, with patients' age ranging from 3 months to 98 years. SE incidence peaked in the first year of life, and 59.4% of the individuals had previous epilepsy while 40.6% had not. the main underlying causes were noncompliance to treatment in the first group, and CNS infection, stroke and metabolic disturbances in the second group. Overall mortality was 19.8%. and deaths were correlated to aetiology and patient's age. Refractory SE affected 11.7% of the cases. Clinical types included focal, secondarily generalised and generalised SE. Clinical and clinicoelectrographic classifications were convergent, but EEG was essential for the diagnosis in 4.5% of the cases.Conclusions: Epileptic patients are at greater risk to develop SE, however, individuals with no prior history of epilepsy and acute neurological problems can also present SE. Aetiology varies with patient's age, and mortality is high and related to age and underlying causes. Clinical and clinicoelectrographic classifications are usually convergent, but in some cases the diagnosis of SE would not be established without the EEG. (C) 2003 BEA Trading Ltd. Published by Elsevier B.V. All rights reserved.
publishDate 2003
dc.date.none.fl_str_mv 2003-09-01
2016-01-24T12:34:00Z
2016-01-24T12:34:00Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/S1059-1311(02)00324-2
Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 12, n. 6, p. 337-345, 2003.
10.1016/S1059-1311(02)00324-2
WOS000185039300003.pdf
1059-1311
http://repositorio.unifesp.br/handle/11600/27369
WOS:000185039300003
dc.identifier.dark.fl_str_mv ark:/48912/001300002tf7p
url http://dx.doi.org/10.1016/S1059-1311(02)00324-2
http://repositorio.unifesp.br/handle/11600/27369
identifier_str_mv Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 12, n. 6, p. 337-345, 2003.
10.1016/S1059-1311(02)00324-2
WOS000185039300003.pdf
1059-1311
WOS:000185039300003
ark:/48912/001300002tf7p
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Seizure-european Journal of Epilepsy
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 337-345
application/pdf
dc.publisher.none.fl_str_mv W B Saunders Co Ltd
publisher.none.fl_str_mv W B Saunders Co Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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score 15,300719

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