Production of Clostridium perfringens type A antitoxin, on industrial scale

A method is described for the preparation of Clostridium perfringens type A antitoxin, on industrial scale, by the hyperimmuniza.tion of horses with mixed alum-adsorbed antigen. With the use of the immunization method idealized in laboratory of Instituto Butantan, São Paulo, an antigangrenousCl. per...

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Detalles Bibliográficos
Autores: Silva, Maria Antonieta da, Ilzuka, Hideyo, Oliveira, Edison Paulo Tavares de, Higashi, Hisako Gondo, Rolim-Rosa, Raymundo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:1981
País:Brasil
Institución:Instituto Adolfo Lutz
Repositorio:Revista do Instituto Adolfo Lutz (Online)
Idioma:portugués
OAI Identifier:oai:ojs.periodicos.saude.sp.gov.br:article/36986
Acceso en línea:https://periodicos.saude.sp.gov.br/RIAL/article/view/36986
Access Level:acceso abierto
Palabra clave:gas gangrene
Clostridium perfringens type A antitoxin
antigens, bacterial
horses, immunization
antitoxins, gas gangrene C. perfringens
gangrena gasosa
Clostridium perfringens, antitoxina tipo A
antígenos bacterianos
cavalos, imunização
soro antigangrenoso perfríngico
id BR_38e722d2ffa906ccc8f47e272bbd548a
oai_identifier_str oai:ojs.periodicos.saude.sp.gov.br:article/36986
network_acronym_str BR
network_name_str Brasil
repository_id_str
spelling Production of Clostridium perfringens type A antitoxin, on industrial scaleObtenção de antitoxina perfringens do tipo A em escala industrialgas gangreneClostridium perfringens type A antitoxinantigens, bacterialhorses, immunizationantitoxins, gas gangrene C. perfringensgangrena gasosaClostridium perfringens, antitoxina tipo Aantígenos bacterianoscavalos, imunizaçãosoro antigangrenoso perfríngicoA method is described for the preparation of Clostridium perfringens type A antitoxin, on industrial scale, by the hyperimmuniza.tion of horses with mixed alum-adsorbed antigen. With the use of the immunization method idealized in laboratory of Instituto Butantan, São Paulo, an antigangrenousCl. perfringens type A antitoxin was obtained with a dos age of about 2'00 lU Iml, a titre that after concentration by .Pope's method, increased to antitoxic Ievels of 850 to 1.000 lU Iml. The purified and concentrated antitoxin was conveniently diluted to constitute a polyvalent gas gangrene antitoxin.Descreve-se o método utilizado na preparação da antitoxina perfríngica do tipo A, em escala industrial, pela hiperimunização de cavalos, através de antígeno misto, adsorvído pelo alúmen de potássio. Empregando-se esquema de imunização próprio, conseguiu-se obter soro antigangrenoso perfríngico tipo A, dosando ao redor de 200 UI/ml, título este que, após a concentração pelo método de Pope, elevou-se ao nível antitóxico de 850 a 1.000 UI/ml. O soro purificado e concentrado foi diluído convenientemente para compor o soro antigangrenoso polivalente.Instituto Adolfo Lutz1981-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfhttps://periodicos.saude.sp.gov.br/RIAL/article/view/3698610.53393/rial.1981.41.36986Instituto Adolfo Lutz Journal - RIAL; Vol. 41 No. 1 (1981); 1-8Revista del Instituto Adolfo Lutz - RIAL; Vol. 41 Núm. 1 (1981); 1-8Revista do Instituto Adolfo Lutz; v. 41 n. 1 (1981); 1-81983-38140073-9855reponame:Revista do Instituto Adolfo Lutz (Online)instname:Instituto Adolfo Lutzinstacron:IALporhttps://periodicos.saude.sp.gov.br/RIAL/article/view/36986/35186Copyright (c) 1981 Maria Antonieta da Silva, Hideyo Ilzuka, Edison Paulo Tavares de Oliveira, Hisako Gondo Higashi, Raymundo Rolim-Rosainfo:eu-repo/semantics/openAccessSilva, Maria Antonieta daIlzuka, HideyoOliveira, Edison Paulo Tavares deHigashi, Hisako GondoRolim-Rosa, Raymundo2024-02-29T18:41:23Zoai:ojs.periodicos.saude.sp.gov.br:article/36986Revistahttps://periodicos.saude.sp.gov.br/RIAL/indexPUBhttps://periodicos.saude.sp.gov.br/RIAL/oairial@saude.sp.gov.brhttps://doi.org/10.53393/rial1983-38140073-9855opendoar:2024-02-29T18:41:23Revista do Instituto Adolfo Lutz (Online) - Instituto Adolfo Lutzfalse
dc.title.none.fl_str_mv Production of Clostridium perfringens type A antitoxin, on industrial scale
Obtenção de antitoxina perfringens do tipo A em escala industrial
title Production of Clostridium perfringens type A antitoxin, on industrial scale
spellingShingle Production of Clostridium perfringens type A antitoxin, on industrial scale
Silva, Maria Antonieta da
gas gangrene
Clostridium perfringens type A antitoxin
antigens, bacterial
horses, immunization
antitoxins, gas gangrene C. perfringens
gangrena gasosa
Clostridium perfringens, antitoxina tipo A
antígenos bacterianos
cavalos, imunização
soro antigangrenoso perfríngico
title_short Production of Clostridium perfringens type A antitoxin, on industrial scale
title_full Production of Clostridium perfringens type A antitoxin, on industrial scale
title_fullStr Production of Clostridium perfringens type A antitoxin, on industrial scale
title_full_unstemmed Production of Clostridium perfringens type A antitoxin, on industrial scale
title_sort Production of Clostridium perfringens type A antitoxin, on industrial scale
dc.creator.none.fl_str_mv Silva, Maria Antonieta da
Ilzuka, Hideyo
Oliveira, Edison Paulo Tavares de
Higashi, Hisako Gondo
Rolim-Rosa, Raymundo
author Silva, Maria Antonieta da
author_facet Silva, Maria Antonieta da
Ilzuka, Hideyo
Oliveira, Edison Paulo Tavares de
Higashi, Hisako Gondo
Rolim-Rosa, Raymundo
author_role author
author2 Ilzuka, Hideyo
Oliveira, Edison Paulo Tavares de
Higashi, Hisako Gondo
Rolim-Rosa, Raymundo
author2_role author
author
author
author
dc.subject.por.fl_str_mv gas gangrene
Clostridium perfringens type A antitoxin
antigens, bacterial
horses, immunization
antitoxins, gas gangrene C. perfringens
gangrena gasosa
Clostridium perfringens, antitoxina tipo A
antígenos bacterianos
cavalos, imunização
soro antigangrenoso perfríngico
topic gas gangrene
Clostridium perfringens type A antitoxin
antigens, bacterial
horses, immunization
antitoxins, gas gangrene C. perfringens
gangrena gasosa
Clostridium perfringens, antitoxina tipo A
antígenos bacterianos
cavalos, imunização
soro antigangrenoso perfríngico
description A method is described for the preparation of Clostridium perfringens type A antitoxin, on industrial scale, by the hyperimmuniza.tion of horses with mixed alum-adsorbed antigen. With the use of the immunization method idealized in laboratory of Instituto Butantan, São Paulo, an antigangrenousCl. perfringens type A antitoxin was obtained with a dos age of about 2'00 lU Iml, a titre that after concentration by .Pope's method, increased to antitoxic Ievels of 850 to 1.000 lU Iml. The purified and concentrated antitoxin was conveniently diluted to constitute a polyvalent gas gangrene antitoxin.
publishDate 1981
dc.date.none.fl_str_mv 1981-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.saude.sp.gov.br/RIAL/article/view/36986
10.53393/rial.1981.41.36986
url https://periodicos.saude.sp.gov.br/RIAL/article/view/36986
identifier_str_mv 10.53393/rial.1981.41.36986
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.saude.sp.gov.br/RIAL/article/view/36986/35186
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Adolfo Lutz
publisher.none.fl_str_mv Instituto Adolfo Lutz
dc.source.none.fl_str_mv Instituto Adolfo Lutz Journal - RIAL; Vol. 41 No. 1 (1981); 1-8
Revista del Instituto Adolfo Lutz - RIAL; Vol. 41 Núm. 1 (1981); 1-8
Revista do Instituto Adolfo Lutz; v. 41 n. 1 (1981); 1-8
1983-3814
0073-9855
reponame:Revista do Instituto Adolfo Lutz (Online)
instname:Instituto Adolfo Lutz
instacron:IAL
instname_str Instituto Adolfo Lutz
instacron_str IAL
institution IAL
reponame_str Revista do Instituto Adolfo Lutz (Online)
collection Revista do Instituto Adolfo Lutz (Online)
repository.name.fl_str_mv Revista do Instituto Adolfo Lutz (Online) - Instituto Adolfo Lutz
repository.mail.fl_str_mv rial@saude.sp.gov.br
_version_ 1853663538443190272
score 15,301629

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