Production of Clostridium perfringens type A antitoxin, on industrial scale
A method is described for the preparation of Clostridium perfringens type A antitoxin, on industrial scale, by the hyperimmuniza.tion of horses with mixed alum-adsorbed antigen. With the use of the immunization method idealized in laboratory of Instituto Butantan, São Paulo, an antigangrenousCl. per...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 1981 |
| País: | Brasil |
| Institución: | Instituto Adolfo Lutz |
| Repositorio: | Revista do Instituto Adolfo Lutz (Online) |
| Idioma: | portugués |
| OAI Identifier: | oai:ojs.periodicos.saude.sp.gov.br:article/36986 |
| Acceso en línea: | https://periodicos.saude.sp.gov.br/RIAL/article/view/36986 |
| Access Level: | acceso abierto |
| Palabra clave: | gas gangrene Clostridium perfringens type A antitoxin antigens, bacterial horses, immunization antitoxins, gas gangrene C. perfringens gangrena gasosa Clostridium perfringens, antitoxina tipo A antígenos bacterianos cavalos, imunização soro antigangrenoso perfríngico |
| Sumario: | A method is described for the preparation of Clostridium perfringens type A antitoxin, on industrial scale, by the hyperimmuniza.tion of horses with mixed alum-adsorbed antigen. With the use of the immunization method idealized in laboratory of Instituto Butantan, São Paulo, an antigangrenousCl. perfringens type A antitoxin was obtained with a dos age of about 2'00 lU Iml, a titre that after concentration by .Pope's method, increased to antitoxic Ievels of 850 to 1.000 lU Iml. The purified and concentrated antitoxin was conveniently diluted to constitute a polyvalent gas gangrene antitoxin. |
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