Multidrug Resistant Acinetobacer baumanni: the occurrence of polymyxin resistance in Rio de Janeiro
Higher prevalence of carbapenem-resistant A. baumannii infections has led to the return of old antimicrobials, such as polymyxins, “last-resort” drugs for the clinical therapy. This study aimed to determine the susceptibility profile of 60 A. baumannii isolates from a hospital in the city of Rio de...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | Brasil |
| Institución: | Fundação Oswaldo Cruz (FIOCRUZ) |
| Repositorio: | Vigilância Sanitária em Debate |
| Idioma: | portugués |
| OAI Identifier: | oai:ojs.visaemdebate.incqs.fiocruz.br:article/732 |
| Acceso en línea: | https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/732 |
| Access Level: | acceso abierto |
| Palabra clave: | Acinetobacter baumannii Resistência Polimixina B Infecção Hospitalar Vigilância Sanitária Resistance Polymyxin B Hospital Infections Sanitary Surveillance |
| Sumario: | Higher prevalence of carbapenem-resistant A. baumannii infections has led to the return of old antimicrobials, such as polymyxins, “last-resort” drugs for the clinical therapy. This study aimed to determine the susceptibility profile of 60 A. baumannii isolates from a hospital in the city of Rio de Janeiro, 27 isolates obtained from patients in an outbreak in 2011, and a total of 33 isolates from both patients and the hospital environment collected in the 2014-15 period, in the same hospital. Isolates showed high levels (≥ 80%) of resistance to the antimicrobials tested: piperacillin/tazobactam, cefotaxime, ciprofloxacin, cefepime, imipenem and meropenem. The highest resistance percentage presented in isolates from the 2011 period was to ciprofloxacin (96%). Regarding the environmental isolates, the highest resistance percentage was found to cefotaxime (94%). Among the 60 isolates tested, 19 (32%) were sensible to polymyxin B (MIC ≤ 2 mg/mL) and 41 (68%) were resistant (MIC ≥ 4 mg/mL), 27 were obtained from patients (20 from the 2011 period and 7 from the 2014-2015 period) and 14 from the hospital environment. The resistance to polymyxins is still rare; however, the extensive use of polymyxins has led to the emergence of resistant strains of A. baumannii. |
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