Tratamento da leucemia linfoblástica do adulto: resultados do protocolo de alto risco do GBTLI85 comparados retrospectivamente com um esquema convencional

In a Group of 43 patients aged over 15 years with a diagnosis of Acute Lymphoblastic Leukemia (ALL), there were compared retrospectively the resuits of the modified Stein protocol (Group 1) and the GBTLI85 (Group 2) regimen, a intensive protocol developed for high risk childhoodALL. The Complete Res...

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Detalles Bibliográficos
Autores: Fenelon, Alexandre José Silva, Pinto, Carlos Frederico Distefano, Moreira, Wagner Brant, Cabral Filho, Sebastião, Brandão, Eduardo Carvalho, Lopes, Eugênio Baumgratz, Vieira, Maria do Carmo Lima, Álvares, Maria Nunes, Teixeira, João Augusto Moreira, Nascimento, Eduardo, Novaes, Nedda Maria Vasconcelos
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:Brasil
Institución:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
Repositorio:Revista Brasileira de Cancerologia (Online)
Idioma:portugués
OAI Identifier:oai:rbc.inca.gov.br:article/3009
Acceso en línea:https://rbc.inca.gov.br/index.php/revista/article/view/3009
Access Level:acceso abierto
Palabra clave:Leucemia Linfoblástica Aguda
Quimioterapia
Acute Lymphoblastic Leukemia
Chemotherapy
Descripción
Sumario:In a Group of 43 patients aged over 15 years with a diagnosis of Acute Lymphoblastic Leukemia (ALL), there were compared retrospectively the resuits of the modified Stein protocol (Group 1) and the GBTLI85 (Group 2) regimen, a intensive protocol developed for high risk childhoodALL. The Complete Response (CR) rate was better in Group 2 (54% vs. 19%,p = 0.01), but this difference had lost statistical significance after a multivariate analysis. Once a CR was obtained, the 4 year disease-free survival was 25% for both groups, butin Group 1 the relapse rate was 75% and in Group 2, the relapse rate ivas 41 % and 33% of the responders died from toxicity of post remission therapy. The 4 years failure free survival (FFS) was 4% for Group 1 (95% confidence interval 0-13%) and 13% for Group 2 (95%) confidence interval 0-27%). In our patients, an intensive therapy based in the high risk childhood protocols had failed in improving the cure rates and was associated to prohibitive toxicity rates. New approaches based in risk grouping for adult ALL must be found.

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