Designing improved active peptides for therapeutic approaches against infectious diseases

Infectious diseases are one of the main causes of human morbidity and mortality. In the last few decades, pathogenic microorganisms’ resistance to conventional drugs has been increasing, and it is now pinpointed as a major worldwide health concern. The need to search for new therapeutic options, as...

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Autores: Gomes, Bárbara, Augusto, Marcelo T., Felício, Mário R., Hollmann, Axel, Franco, Octávio L., Gonçalves, Sónia, Santos, Nuno C.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/98840
Acceso en línea:http://hdl.handle.net/11336/98840
Access Level:acceso abierto
Palabra clave:ANTIMICROBIAL PEPTIDES
ANTIVIRAL PEPTIDES
BIOLOGICALLY ACTIVE PEPTIDES
CELL-PENETRATING PEPTIDES
PEPTIDE-BASED DRUGS
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
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spelling Designing improved active peptides for therapeutic approaches against infectious diseasesGomes, BárbaraAugusto, Marcelo T.Felício, Mário R.Hollmann, AxelFranco, Octávio L.Gonçalves, SóniaSantos, Nuno C.ANTIMICROBIAL PEPTIDESANTIVIRAL PEPTIDESBIOLOGICALLY ACTIVE PEPTIDESCELL-PENETRATING PEPTIDESPEPTIDE-BASED DRUGShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Infectious diseases are one of the main causes of human morbidity and mortality. In the last few decades, pathogenic microorganisms’ resistance to conventional drugs has been increasing, and it is now pinpointed as a major worldwide health concern. The need to search for new therapeutic options, as well as improved treatment outcomes, has therefore increased significantly, with biologically active peptides representing a new alternative. A substantial research effort is being dedicated towards their development, especially due to improved biocompatibility and target selectivity. However, the inherent limitations of peptide drugs are restricting their application. In this review, we summarize the current status of peptide drug development, focusing on antiviral and antimicrobial peptide activities, highlighting the design improvements needed, and those already being used, to overcome the drawbacks of the therapeutic application of biologically active peptides.Fil: Gomes, Bárbara. Universidad de Lisboa; PortugalFil: Augusto, Marcelo T.. Universidad de Lisboa; PortugalFil: Felício, Mário R.. Universidad de Lisboa; PortugalFil: Hollmann, Axel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Santiago del Estero. Universidad Nacional de Santiago del Estero. Centro de Investigaciones y Transferencia de Santiago del Estero; Argentina. Universidad de Lisboa; Portugal. Universidad Nacional de Quilmes; ArgentinaFil: Franco, Octávio L.. Universidade do Brasília; Brasil. Universidad Católica de Brasilia; Brasil. Universidad Católica Don Bosco; BrasilFil: Gonçalves, Sónia. Universidad de Lisboa; PortugalFil: Santos, Nuno C.. Universidad de Lisboa; PortugalPergamon-Elsevier Science Ltd2018-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/98840Gomes, Bárbara; Augusto, Marcelo T.; Felício, Mário R.; Hollmann, Axel; Franco, Octávio L.; et al.; Designing improved active peptides for therapeutic approaches against infectious diseases; Pergamon-Elsevier Science Ltd; Biotechnology Advances; 36; 2; 3-2018; 415-4290734-9750CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S0734975018300041info:eu-repo/semantics/altIdentifier/doi/10.1016/j.biotechadv.2018.01.004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:33:41Zoai:ri.conicet.gov.ar:11336/98840instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:33:41.449CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Designing improved active peptides for therapeutic approaches against infectious diseases
title Designing improved active peptides for therapeutic approaches against infectious diseases
spellingShingle Designing improved active peptides for therapeutic approaches against infectious diseases
Gomes, Bárbara
ANTIMICROBIAL PEPTIDES
ANTIVIRAL PEPTIDES
BIOLOGICALLY ACTIVE PEPTIDES
CELL-PENETRATING PEPTIDES
PEPTIDE-BASED DRUGS
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Designing improved active peptides for therapeutic approaches against infectious diseases
title_full Designing improved active peptides for therapeutic approaches against infectious diseases
title_fullStr Designing improved active peptides for therapeutic approaches against infectious diseases
title_full_unstemmed Designing improved active peptides for therapeutic approaches against infectious diseases
title_sort Designing improved active peptides for therapeutic approaches against infectious diseases
dc.creator.none.fl_str_mv Gomes, Bárbara
Augusto, Marcelo T.
Felício, Mário R.
Hollmann, Axel
Franco, Octávio L.
Gonçalves, Sónia
Santos, Nuno C.
author Gomes, Bárbara
author_facet Gomes, Bárbara
Augusto, Marcelo T.
Felício, Mário R.
Hollmann, Axel
Franco, Octávio L.
Gonçalves, Sónia
Santos, Nuno C.
author_role author
author2 Augusto, Marcelo T.
Felício, Mário R.
Hollmann, Axel
Franco, Octávio L.
Gonçalves, Sónia
Santos, Nuno C.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTIMICROBIAL PEPTIDES
ANTIVIRAL PEPTIDES
BIOLOGICALLY ACTIVE PEPTIDES
CELL-PENETRATING PEPTIDES
PEPTIDE-BASED DRUGS
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic ANTIMICROBIAL PEPTIDES
ANTIVIRAL PEPTIDES
BIOLOGICALLY ACTIVE PEPTIDES
CELL-PENETRATING PEPTIDES
PEPTIDE-BASED DRUGS
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description Infectious diseases are one of the main causes of human morbidity and mortality. In the last few decades, pathogenic microorganisms’ resistance to conventional drugs has been increasing, and it is now pinpointed as a major worldwide health concern. The need to search for new therapeutic options, as well as improved treatment outcomes, has therefore increased significantly, with biologically active peptides representing a new alternative. A substantial research effort is being dedicated towards their development, especially due to improved biocompatibility and target selectivity. However, the inherent limitations of peptide drugs are restricting their application. In this review, we summarize the current status of peptide drug development, focusing on antiviral and antimicrobial peptide activities, highlighting the design improvements needed, and those already being used, to overcome the drawbacks of the therapeutic application of biologically active peptides.
publishDate 2018
dc.date.none.fl_str_mv 2018-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/98840
Gomes, Bárbara; Augusto, Marcelo T.; Felício, Mário R.; Hollmann, Axel; Franco, Octávio L.; et al.; Designing improved active peptides for therapeutic approaches against infectious diseases; Pergamon-Elsevier Science Ltd; Biotechnology Advances; 36; 2; 3-2018; 415-429
0734-9750
CONICET Digital
CONICET
url http://hdl.handle.net/11336/98840
identifier_str_mv Gomes, Bárbara; Augusto, Marcelo T.; Felício, Mário R.; Hollmann, Axel; Franco, Octávio L.; et al.; Designing improved active peptides for therapeutic approaches against infectious diseases; Pergamon-Elsevier Science Ltd; Biotechnology Advances; 36; 2; 3-2018; 415-429
0734-9750
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S0734975018300041
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.biotechadv.2018.01.004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15.812429

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