Bactericidal and Hemolytic Activities of Synthetic Peptides Derived from Granulysin

Granulysin is a human polypeptide produced by cytolytic cells active against a broad range of microbes. Three peptides covering the regions 25-50 (Gr-1 and Gr-2) and 39-62 (Gr-3) of granulysin were synthesized, and their in vitro activity against Mycobacterium tuberculosis was evaluated. The most ac...

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Bibliographic Details
Authors: Siano, Alvaro Sebastían, Tonarelli, Georgina Guadalupe, Imaz, María Susana, Perín, Juan Carlos, Ruggeri, María Natalia, Lopez, M., Santi, Maria Noemi, Zerbini, Elsa Virginia
Format: article
Status:Published version
Publication Date:2010
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/98388
Online Access:http://hdl.handle.net/11336/98388
Access Level:Open access
Keyword:ANTIMICROBIAL PEPTIDES
GRANULYSIN
MYCOBACTERIUM TUBERCULOSIS
SYNTHETIC PEPTIDES
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
Description
Summary:Granulysin is a human polypeptide produced by cytolytic cells active against a broad range of microbes. Three peptides covering the regions 25-50 (Gr-1 and Gr-2) and 39-62 (Gr-3) of granulysin were synthesized, and their in vitro activity against Mycobacterium tuberculosis was evaluated. The most active peptide was Gr-1C, containing a disulphide bridge, with Minimal Inhibitory Concentration value of 10.1 μM. In concentrations of up to 50 μM, Gr-1 and Gr2 didn't exceed 30% of hemolysis.

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