First total synthesis of (+)-Neplanocin B
(+)-Neplanocin B ((+)-5), the unnatural isomer of a minor component of the neplanocin family of antibiotics was enantioselectively synthesized starting from D-ribono-1,4-lactone. This synthetic strategy employed (+)-9-[(1R, 2R, 5S)-5-Benzyloxy-3-(benzyloxy)methyl-2-hydroxycyclopent-3-en-1-yl]-6-chlo...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2005 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/92317 |
| Acceso en línea: | http://hdl.handle.net/11336/92317 |
| Access Level: | acceso abierto |
| Palabra clave: | Carbocyclic nucleosides Neplanocin B Conformationally locked nucleosides 6- oxabicyclo[3.1.0]hexane Ampullariella regularis https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Sumario: | (+)-Neplanocin B ((+)-5), the unnatural isomer of a minor component of the neplanocin family of antibiotics was enantioselectively synthesized starting from D-ribono-1,4-lactone. This synthetic strategy employed (+)-9-[(1R, 2R, 5S)-5-Benzyloxy-3-(benzyloxy)methyl-2-hydroxycyclopent-3-en-1-yl]-6-chloropurine (compound 7) as an advanced synthetic intermediate. |
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