Impaired mesial synchronization in temporal lobe epilepsy
Objective: Temporal lobe epilepsy is commonly associated with synchronous, hyper-synchronous and des-synchronous activity. The aim of the present work is to explore synchronization activity in both mesial areas in temporal lobe epileptic patients during the interictal state. Methods: Using a cluster...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2011 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/194671 |
| Acceso en línea: | http://hdl.handle.net/11336/194671 |
| Access Level: | acceso abierto |
| Palabra clave: | CLUSTERS COMPLEXITY FORAMEN OVALE ELECTRODES SYNCHRONIZATION TEMPORAL LOBE EPILEPSY VIDEO-ELECTROENCEPHALOGRAPHY https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
| Sumario: | Objective: Temporal lobe epilepsy is commonly associated with synchronous, hyper-synchronous and des-synchronous activity. The aim of the present work is to explore synchronization activity in both mesial areas in temporal lobe epileptic patients during the interictal state. Methods: Using a cluster technique, we analyzed 17 temporal lobe epilepsy patients’ records of foramen ovale electrodes activity during the inter-ictal state. Results: There exists a clear tendency in the mesial area of the epileptic side to be organized as isolated clusters of electrical activity as compared with the contra-lateral side, which is organized in the form of large clusters of synchronous activity. The number of desynchronized areas is larger in the epileptic side than in the contra-lateral side in 16 out of 17 temporal lobe epileptic patients. Conclusions: The mesial area responsible for the seizures is less synchronous than the contra-lateral; the different kind of synchronous organization accounts for a lower synchronization activity at the epileptic side, suggesting that this lack of synchronous cluster organization would favour the appearance of seizures. Significance: Our results shed new light regarding synchronization issues in temporal lobe epilepsy and also it would help in reducing drastically the time of study. |
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