Development and validation of a mechanistic model for the release of embelin from a polycaprolactone matrix
Embelin is a natural agent with antimicrobial, antifungal and analgesic activities. This work presents a mechanistic model for the release of embelin from a polycaprolactone matrix. Based on the results of embelin release experiments and Raman microscopy measurements, the model assumes a dual disper...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/144087 |
| Acceso en línea: | http://hdl.handle.net/11336/144087 |
| Access Level: | acceso abierto |
| Palabra clave: | DRUG RELEASE EMBELIN MECHANISTIC MODEL POLYCAPROLACTONE https://purl.org/becyt/ford/2.5 https://purl.org/becyt/ford/2 https://purl.org/becyt/ford/2.9 |
| Sumario: | Embelin is a natural agent with antimicrobial, antifungal and analgesic activities. This work presents a mechanistic model for the release of embelin from a polycaprolactone matrix. Based on the results of embelin release experiments and Raman microscopy measurements, the model assumes a dual dispersion of the embelin: agglomerated and dispersed. Embelin release mechanism combines the effects of the liquid migration into the matrix, the drug diffusion, and the drug dissolution within the wetted matrix. The model is formulated in terms of four partial differential equations that account for the mass balances of dispersed, agglomerated, and dissolved embelin, and aqueous solution. Model predictions show that the release mechanism involves three stages: a burst stage, in which dispersed embelin is rapidly released; a transition stage, in which dispersed and agglomerated embelin are simultaneously released; and, once the dispersed embelin depletion, a stable release stage until the agglomerated embelin exhausts. |
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