Multicomponent synthesis of antibacterial dihydropyridin and dihydropyran embelin derivative
A series of dihydropyran and dihydropyridin embelin derivatives were synthesized through a novel and straightforward, one pot protocol based on a three component reaction with embelin, aldehydes and cyclic enaminones as synthetic imputs. The type of substituent on the nitrogen atom of the β-enaminon...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2013 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/25011 |
| Acceso en línea: | http://hdl.handle.net/11336/25011 |
| Access Level: | acceso abierto |
| Palabra clave: | MULTICOMPONENT SYNTESIS ANTIBACTERIAL DIHYDROPYRIDIN EMBELIN DERIVATIVES DIHYDROPYRAN EMBELIN DERIVATIVES https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Sumario: | A series of dihydropyran and dihydropyridin embelin derivatives were synthesized through a novel and straightforward, one pot protocol based on a three component reaction with embelin, aldehydes and cyclic enaminones as synthetic imputs. The type of substituent on the nitrogen atom of the β-enaminone is key to obtain nitrogenated or oxygenated rings. The obtained compounds were active against Gram-positive bacteria, including multiresistant Staphylococcus aureus clinical isolates |
|---|