Microwave Assisted Synthesis of ethyl-quinolon-4-one-3-carboxylates and Hydrolysis to quinolon-4-one-3-carboxylic Acids
A fast and efficient microwave assisted synthesis of several ethyl-quinolon-4-one-3-carboxylates and quinolon- 4-one-3-carboxylic acids has been developed. The 3-carboethoxy quinolones are easily obtained in a one-pot procedure through the cyclization of aminomethylenemalonate intermediates obtained...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/31507 |
| Acceso en línea: | http://hdl.handle.net/11336/31507 |
| Access Level: | acceso abierto |
| Palabra clave: | Carboxylic Acids Catalysis Cyclization Hydrolysis Malonates Microwave Open-Vessel Quinolones Sealed-Vessel Thermolysis https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Sumario: | A fast and efficient microwave assisted synthesis of several ethyl-quinolon-4-one-3-carboxylates and quinolon- 4-one-3-carboxylic acids has been developed. The 3-carboethoxy quinolones are easily obtained in a one-pot procedure through the cyclization of aminomethylenemalonate intermediates obtained by reaction of different p-substituted anilines and diethyl-ethoxymethylenmalonate. These quinolones are then irradiated under base hydrolysis conditions to get the carboxylic acids through a very fast and clean approach. |
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