Neuroimmune aspects of Sjögren's syndrome: Role of VIP/VPAC system in immune and salivary gland epithelial cell function

Sjögren's syndrome (SS) is a chronic inflammatory disease characterized by salivary and lacrimal gland dysfunction although extraglandular manifestations are also found. Suitable study models and in vitro cell culture designs are used to approach SS pathogenic mechanisms. Cellular and molecular...

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Autores: Hauk, Vanesa Cintia, Calafat, Mario Jose, Grasso, Esteban Nicolas, Fraccaroli, Laura Virginia, Paparini, Daniel Esteban, Ramhorst, Rosanna Elizabeth, Perez Leiros, Claudia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/39781
Acceso en línea:http://hdl.handle.net/11336/39781
Access Level:acceso abierto
Palabra clave:Salivary Epithelial Cells
SjÖGren Syndrome
Vasoactive Intestinal Peptide
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
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network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Neuroimmune aspects of Sjögren's syndrome: Role of VIP/VPAC system in immune and salivary gland epithelial cell function
title Neuroimmune aspects of Sjögren's syndrome: Role of VIP/VPAC system in immune and salivary gland epithelial cell function
spellingShingle Neuroimmune aspects of Sjögren's syndrome: Role of VIP/VPAC system in immune and salivary gland epithelial cell function
Hauk, Vanesa Cintia
Salivary Epithelial Cells
SjÖGren Syndrome
Vasoactive Intestinal Peptide
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Neuroimmune aspects of Sjögren's syndrome: Role of VIP/VPAC system in immune and salivary gland epithelial cell function
title_full Neuroimmune aspects of Sjögren's syndrome: Role of VIP/VPAC system in immune and salivary gland epithelial cell function
title_fullStr Neuroimmune aspects of Sjögren's syndrome: Role of VIP/VPAC system in immune and salivary gland epithelial cell function
title_full_unstemmed Neuroimmune aspects of Sjögren's syndrome: Role of VIP/VPAC system in immune and salivary gland epithelial cell function
title_sort Neuroimmune aspects of Sjögren's syndrome: Role of VIP/VPAC system in immune and salivary gland epithelial cell function
dc.creator.none.fl_str_mv Hauk, Vanesa Cintia
Calafat, Mario Jose
Grasso, Esteban Nicolas
Fraccaroli, Laura Virginia
Paparini, Daniel Esteban
Ramhorst, Rosanna Elizabeth
Perez Leiros, Claudia
author Hauk, Vanesa Cintia
author_facet Hauk, Vanesa Cintia
Calafat, Mario Jose
Grasso, Esteban Nicolas
Fraccaroli, Laura Virginia
Paparini, Daniel Esteban
Ramhorst, Rosanna Elizabeth
Perez Leiros, Claudia
author_role author
author2 Calafat, Mario Jose
Grasso, Esteban Nicolas
Fraccaroli, Laura Virginia
Paparini, Daniel Esteban
Ramhorst, Rosanna Elizabeth
Perez Leiros, Claudia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Salivary Epithelial Cells
SjÖGren Syndrome
Vasoactive Intestinal Peptide
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic Salivary Epithelial Cells
SjÖGren Syndrome
Vasoactive Intestinal Peptide
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description Sjögren's syndrome (SS) is a chronic inflammatory disease characterized by salivary and lacrimal gland dysfunction although extraglandular manifestations are also found. Suitable study models and in vitro cell culture designs are used to approach SS pathogenic mechanisms. Cellular and molecular pathways involved in gland homeostasis loss and the autoimmune response are focused in the search of novel drug targets and biomarkers. Vasoactive intestinal peptide (VIP) has trophic, pro-secretory and immunomodulatory effects in several chronic and autoimmune disease models. Here we review evidence pointing to its role as an endogenous modulator of gland homeostasis at early stages of the disease. Particularly, mechanisms involving VIP/VPAC system in the course of salivary function impairment in the non obese diabetic (NOD) mouse model of Sjögren's syndrome are described.
publishDate 2014
dc.date.none.fl_str_mv 2014-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39781
Hauk, Vanesa Cintia; Calafat, Mario Jose; Grasso, Esteban Nicolas; Fraccaroli, Laura Virginia; Paparini, Daniel Esteban; et al.; Neuroimmune aspects of Sjögren's syndrome: Role of VIP/VPAC system in immune and salivary gland epithelial cell function; Bentham Science Publishers; Current Pharmaceutical Design; 20; 29; 1-2014; 4760-4765
1381-6128
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39781
identifier_str_mv Hauk, Vanesa Cintia; Calafat, Mario Jose; Grasso, Esteban Nicolas; Fraccaroli, Laura Virginia; Paparini, Daniel Esteban; et al.; Neuroimmune aspects of Sjögren's syndrome: Role of VIP/VPAC system in immune and salivary gland epithelial cell function; Bentham Science Publishers; Current Pharmaceutical Design; 20; 29; 1-2014; 4760-4765
1381-6128
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2174/1381612820666140130203636
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/120068/article
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195284538916864
spelling Neuroimmune aspects of Sjögren's syndrome: Role of VIP/VPAC system in immune and salivary gland epithelial cell functionHauk, Vanesa CintiaCalafat, Mario JoseGrasso, Esteban NicolasFraccaroli, Laura VirginiaPaparini, Daniel EstebanRamhorst, Rosanna ElizabethPerez Leiros, ClaudiaSalivary Epithelial CellsSjÖGren SyndromeVasoactive Intestinal Peptidehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Sjögren's syndrome (SS) is a chronic inflammatory disease characterized by salivary and lacrimal gland dysfunction although extraglandular manifestations are also found. Suitable study models and in vitro cell culture designs are used to approach SS pathogenic mechanisms. Cellular and molecular pathways involved in gland homeostasis loss and the autoimmune response are focused in the search of novel drug targets and biomarkers. Vasoactive intestinal peptide (VIP) has trophic, pro-secretory and immunomodulatory effects in several chronic and autoimmune disease models. Here we review evidence pointing to its role as an endogenous modulator of gland homeostasis at early stages of the disease. Particularly, mechanisms involving VIP/VPAC system in the course of salivary function impairment in the non obese diabetic (NOD) mouse model of Sjögren's syndrome are described.Fil: Hauk, Vanesa Cintia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Calafat, Mario Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Grasso, Esteban Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Fraccaroli, Laura Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Paparini, Daniel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Ramhorst, Rosanna Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Perez Leiros, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaBentham Science Publishers2014-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39781Hauk, Vanesa Cintia; Calafat, Mario Jose; Grasso, Esteban Nicolas; Fraccaroli, Laura Virginia; Paparini, Daniel Esteban; et al.; Neuroimmune aspects of Sjögren's syndrome: Role of VIP/VPAC system in immune and salivary gland epithelial cell function; Bentham Science Publishers; Current Pharmaceutical Design; 20; 29; 1-2014; 4760-47651381-6128CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2174/1381612820666140130203636info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/120068/articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:48:01Zoai:ri.conicet.gov.ar:11336/39781instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:48:01.865CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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