Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis
Here we confirm the efficacy of MbΔmce2-phoP to protect mice against bTB challenge and we demonstrated that this new attenuated strain is safer than our previous bTB vaccine MbΔmce2. Altogether these results support the further assessment of this candidate in cattle model of bTB.Experiments with mic...
| Autores: | , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | Argentina |
| Institución: | Instituto Nacional de Tecnología Agropecuaria |
| Repositorio: | INTA Digital (INTA) |
| Idioma: | inglés |
| OAI Identifier: | oai:localhost:20.500.12123/1053 |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/1053 https://jidc.org/index.php/journal/article/view/27580338/1568 https://doi.org/10.3855/jidc.7721 |
| Access Level: | acceso abierto |
| Palabra clave: | Enfermedades de los Animales Mycobacterium Bovis Tuberculosis Infección por Mycobacterium Bovis Animal Diseases Mycobacterium Bovis Infections |
| Sumario: | Here we confirm the efficacy of MbΔmce2-phoP to protect mice against bTB challenge and we demonstrated that this new attenuated strain is safer than our previous bTB vaccine MbΔmce2. Altogether these results support the further assessment of this candidate in cattle model of bTB.Experiments with mice were performed in compliance with the regulations of the Institutional Animal Care and Use Committee (CICUAE) of INTA (61/2014).. |
|---|