Calcium and TFAM crosstalk in the mitochondrial life cycle in cardiomyocytes
Calcium (Ca2+) links the electrical signals of the heart to the mechanical action of contraction in a process referred to as the cardiac excitation-contraction (EC) coupling, a process that consumes a large amount of adenosine triphosphate (ATP). The majority of ATP is produced in the mitochondria v...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | Argentina |
| Institución: | Universidad Nacional de La Plata |
| Repositorio: | SEDICI (UNLP) |
| Idioma: | inglés |
| OAI Identifier: | oai:sedici.unlp.edu.ar:10915/163606 |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/163606 |
| Access Level: | acceso abierto |
| Palabra clave: | Ciencias Médicas Biología mitochondria calcium TFAM cardiomyocytes heart mitocondrias calcio cardiomiocitos corazón |
| Sumario: | Calcium (Ca2+) links the electrical signals of the heart to the mechanical action of contraction in a process referred to as the cardiac excitation-contraction (EC) coupling, a process that consumes a large amount of adenosine triphosphate (ATP). The majority of ATP is produced in the mitochondria via oxidative phosphorylation (OXPHOS), which is linked to Ca2+ flux. The OXPHOS system is regulated by both the nuclear and mitochondrial genome, with mitochondrial transcription factor A (TFAM) being a major regulator of the latter. This mini review focuses on summarizing the limited literature implicating crosstalk between Ca2+ and TFAM in the adult cardiomyocyte throughout the mitochondrial life cycle: mitochondrial dynamics, biogenesis, and mitophagy. The goal of this review is to highlight gaps and fuel further investigation of the proposed Ca2+-TFAM axis. This research area has high potential to propel the development of therapeutic strategies targeting cardiovascular diseases such as heart failure. |
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