Antihistamines potentiate dexamethasone anti-inflammatory effects: Impact on glucocorticoid receptor-mediated expression of inflammation-related genes

Antihistamines and glucocorticoids (GCs) are often used together in the clinic to treat several inflammation-related situations. Although there is no rationale for this association, clinical practice has assumed that, due to their concomitant anti-inflammatory effects, there should be an intrinsic b...

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Detalhes bibliográficos
Autores: Zappia, Carlos Daniel, Torralba Agu, Valeria Nora, Echeverría, Emiliana Beatriz, Fitzsimons, Carlos P., Fernandez, Natalia Cristina, Monczor, Federico
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositório:CONICET Digital (CONICET)
Idioma:inglês
OAI Identifier:oai:ri.conicet.gov.ar:11336/176655
Acesso em linha:http://hdl.handle.net/11336/176655
Access Level:Acceso aberto
Palavra-chave:ANTIHISTAMINES
DEXAMETHASONE
GLUCOCORTICOIDS
HISTAMINE
INFLAMMATION
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
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oai_identifier_str oai:ri.conicet.gov.ar:11336/176655
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Antihistamines potentiate dexamethasone anti-inflammatory effects: Impact on glucocorticoid receptor-mediated expression of inflammation-related genes
title Antihistamines potentiate dexamethasone anti-inflammatory effects: Impact on glucocorticoid receptor-mediated expression of inflammation-related genes
spellingShingle Antihistamines potentiate dexamethasone anti-inflammatory effects: Impact on glucocorticoid receptor-mediated expression of inflammation-related genes
Zappia, Carlos Daniel
ANTIHISTAMINES
DEXAMETHASONE
GLUCOCORTICOIDS
HISTAMINE
INFLAMMATION
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Antihistamines potentiate dexamethasone anti-inflammatory effects: Impact on glucocorticoid receptor-mediated expression of inflammation-related genes
title_full Antihistamines potentiate dexamethasone anti-inflammatory effects: Impact on glucocorticoid receptor-mediated expression of inflammation-related genes
title_fullStr Antihistamines potentiate dexamethasone anti-inflammatory effects: Impact on glucocorticoid receptor-mediated expression of inflammation-related genes
title_full_unstemmed Antihistamines potentiate dexamethasone anti-inflammatory effects: Impact on glucocorticoid receptor-mediated expression of inflammation-related genes
title_sort Antihistamines potentiate dexamethasone anti-inflammatory effects: Impact on glucocorticoid receptor-mediated expression of inflammation-related genes
dc.creator.none.fl_str_mv Zappia, Carlos Daniel
Torralba Agu, Valeria Nora
Echeverría, Emiliana Beatriz
Fitzsimons, Carlos P.
Fernandez, Natalia Cristina
Monczor, Federico
author Zappia, Carlos Daniel
author_facet Zappia, Carlos Daniel
Torralba Agu, Valeria Nora
Echeverría, Emiliana Beatriz
Fitzsimons, Carlos P.
Fernandez, Natalia Cristina
Monczor, Federico
author_role author
author2 Torralba Agu, Valeria Nora
Echeverría, Emiliana Beatriz
Fitzsimons, Carlos P.
Fernandez, Natalia Cristina
Monczor, Federico
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ANTIHISTAMINES
DEXAMETHASONE
GLUCOCORTICOIDS
HISTAMINE
INFLAMMATION
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic ANTIHISTAMINES
DEXAMETHASONE
GLUCOCORTICOIDS
HISTAMINE
INFLAMMATION
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description Antihistamines and glucocorticoids (GCs) are often used together in the clinic to treat several inflammation-related situations. Although there is no rationale for this association, clinical practice has assumed that, due to their concomitant anti-inflammatory effects, there should be an intrinsic benefit to their co-administration. In this work, we evaluated the effects of the co-treatment of several antihistamines on dexamethasone-induced glucocorticoid receptor transcriptional activity on the expression of various inflammation-related genes in A549 and U937 cell lines. Our results show that all antihistamines potentiate GCs’ anti-inflammatory effects, presenting ligand-, cell-and gene-dependent effects. Given that treatment with GCs has strong adverse effects, particularly on bone metabolism, we also examined the impact of antihistamine co-treatment on the expression of bone metabolism markers. Using MC3T3-E1 pre-osteoblastic cells, we observed that, though the antihistamine azelastine reduces the expression of dexamethasone-induced bone loss molecular markers, it potentiates osteoblast apoptosis. Our results suggest that the synergistic effect could contribute to reducing GC clinical doses, ineffective by itself but effective in combination with an antihistamine. This could result in a therapeutic advantage, as the addition of an antihistamine may reinforce the wanted effects of GCs, while related adverse effects could be diminished or at least mitigated. By modulating the patterns of gene activation/repression mediated by GR, antihistamines could enhance only the desired effects of GCs, allowing their effective dose to be reduced. Further research is needed to correctly determine the clinical scope, benefits, and potential risks of this therapeutic strategy.
publishDate 2021
dc.date.none.fl_str_mv 2021-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/176655
Zappia, Carlos Daniel; Torralba Agu, Valeria Nora; Echeverría, Emiliana Beatriz; Fitzsimons, Carlos P.; Fernandez, Natalia Cristina; et al.; Antihistamines potentiate dexamethasone anti-inflammatory effects: Impact on glucocorticoid receptor-mediated expression of inflammation-related genes; MDPI; Cells; 10; 11; 11-2021; 1-15
2073-4409
CONICET Digital
CONICET
url http://hdl.handle.net/11336/176655
identifier_str_mv Zappia, Carlos Daniel; Torralba Agu, Valeria Nora; Echeverría, Emiliana Beatriz; Fitzsimons, Carlos P.; Fernandez, Natalia Cristina; et al.; Antihistamines potentiate dexamethasone anti-inflammatory effects: Impact on glucocorticoid receptor-mediated expression of inflammation-related genes; MDPI; Cells; 10; 11; 11-2021; 1-15
2073-4409
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/cells10113026
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799196247086596096
spelling Antihistamines potentiate dexamethasone anti-inflammatory effects: Impact on glucocorticoid receptor-mediated expression of inflammation-related genesZappia, Carlos DanielTorralba Agu, Valeria NoraEcheverría, Emiliana BeatrizFitzsimons, Carlos P.Fernandez, Natalia CristinaMonczor, FedericoANTIHISTAMINESDEXAMETHASONEGLUCOCORTICOIDSHISTAMINEINFLAMMATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Antihistamines and glucocorticoids (GCs) are often used together in the clinic to treat several inflammation-related situations. Although there is no rationale for this association, clinical practice has assumed that, due to their concomitant anti-inflammatory effects, there should be an intrinsic benefit to their co-administration. In this work, we evaluated the effects of the co-treatment of several antihistamines on dexamethasone-induced glucocorticoid receptor transcriptional activity on the expression of various inflammation-related genes in A549 and U937 cell lines. Our results show that all antihistamines potentiate GCs’ anti-inflammatory effects, presenting ligand-, cell-and gene-dependent effects. Given that treatment with GCs has strong adverse effects, particularly on bone metabolism, we also examined the impact of antihistamine co-treatment on the expression of bone metabolism markers. Using MC3T3-E1 pre-osteoblastic cells, we observed that, though the antihistamine azelastine reduces the expression of dexamethasone-induced bone loss molecular markers, it potentiates osteoblast apoptosis. Our results suggest that the synergistic effect could contribute to reducing GC clinical doses, ineffective by itself but effective in combination with an antihistamine. This could result in a therapeutic advantage, as the addition of an antihistamine may reinforce the wanted effects of GCs, while related adverse effects could be diminished or at least mitigated. By modulating the patterns of gene activation/repression mediated by GR, antihistamines could enhance only the desired effects of GCs, allowing their effective dose to be reduced. Further research is needed to correctly determine the clinical scope, benefits, and potential risks of this therapeutic strategy.Fil: Zappia, Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; ArgentinaFil: Torralba Agu, Valeria Nora. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; ArgentinaFil: Echeverría, Emiliana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; ArgentinaFil: Fitzsimons, Carlos P.. Swammerdam Institute For Life Sciences; Países BajosFil: Fernandez, Natalia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; ArgentinaFil: Monczor, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; ArgentinaMDPI2021-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/176655Zappia, Carlos Daniel; Torralba Agu, Valeria Nora; Echeverría, Emiliana Beatriz; Fitzsimons, Carlos P.; Fernandez, Natalia Cristina; et al.; Antihistamines potentiate dexamethasone anti-inflammatory effects: Impact on glucocorticoid receptor-mediated expression of inflammation-related genes; MDPI; Cells; 10; 11; 11-2021; 1-152073-4409CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/cells10113026info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:20:19Zoai:ri.conicet.gov.ar:11336/176655instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:20:20.21CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
score 15.812429

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