Nanostructured Lipid Carriers Loaded with Dexamethasone Prevent Inflammatory Responses in Primary Non-Parenchymal Liver Cells

Liver inflammation represents a major clinical problem in a wide range of pathologies. Among the strategies to prevent liver failure, dexamethasone (DXM) has been widely used to suppress inflammatory responses. The use of nanocarriers for encapsulation and sustained release of glucocorticoids to liv...

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Detalles Bibliográficos
Autores: Medina Montano, Carolina, Rivero Berti, Ignacio, Gambaro, Rocío Celeste, Limeres, María José, Svensson, Malin, Padula, Gisel, Chain, Cecilia Yamil, Cisneros, José Sebastián, Castro, Guillermo Raul, Grabbe, Stephan, Bros, Matthias, Gehring, Stephan, Islan, German Abel, Cacicedo, Maximiliano Luis
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/213175
Acceso en línea:http://hdl.handle.net/11336/213175
Access Level:acceso abierto
Palabra clave:AUTOIMMUNE HEPATITIS
DEXAMETHASONE
DRUG-CONTROLLED RELEASE
GLUCOCORTICOIDS
LIPID NANOPARTICLES
LIVER IMMUNOLOGY
LIVER INFLAMMATION
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
Descripción
Sumario:Liver inflammation represents a major clinical problem in a wide range of pathologies. Among the strategies to prevent liver failure, dexamethasone (DXM) has been widely used to suppress inflammatory responses. The use of nanocarriers for encapsulation and sustained release of glucocorticoids to liver cells could provide a solution to prevent severe side effects associated with systemic delivery as the conventional treatment regime. Here we describe a nanostructured lipid carrier developed to efficiently encapsulate and release DXM. This nano-formulation proved to be stable over time, did not interact in vitro with plasma opsonins, and was well tolerated by primary non-parenchymal liver cells (NPCs). Released DXM preserved its pharmacological activity, as evidenced by inducing robust anti-inflammatory responses in NPCs. Taken together, nanostructured lipid carriers may constitute a reliable platform for the delivery of DXM to treat pathologies associated with chronic liver inflammation.

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