Human Plasmacytoid Dendritic Cells Elicited Different Responses after Infection with Pathogenic and Nonpathogenic Junin Virus Strains

The Junín virus (JUNV) arenavirus is the etiologic agent of Argentina Haemorrhagic Fever (AHF). We characterised the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection by the C#1 strain (attenuated), and even mor...

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Detalles Bibliográficos
Autores: Negrotto, Soledad, Mena, Hebe Agustina, Ure, Agustin Enrique, Jaquenod de Giusti, Carolina, Bollati Fogolín, Mariela, Vermeulen, Elba Monica, Schattner, Mirta Ana, Gomez, Ricardo Martin
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/48115
Acceso en línea:http://hdl.handle.net/11336/48115
Access Level:acceso abierto
Palabra clave:Argentine haemorrhagic fever
arenavirus
dendritic cells
human
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
Descripción
Sumario:The Junín virus (JUNV) arenavirus is the etiologic agent of Argentina Haemorrhagic Fever (AHF). We characterised the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection by the C#1 strain (attenuated), and even more, by the P (virulent) JUNV strain. However, hpDC elicited different responses in terms of viability, activation, maturation, and cytokine expressions after infection with both JUNV strains.

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