Human plasmacytoid dendritic cells elicited different responses after infection with pathogenic and nonpathogenic Junin virus strains

The arenavirus Junin virus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. We characterized the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection with the C#1 strain (attenuated) and even more susc...

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Detalles Bibliográficos
Autores: Negrotto, Soledad, Mena, Hebe A., Ure, Agustín Enrique, Jaquenod De Giusti, Carolina, Bollati Fogolín, Mariela, Vermeulen, Elba M., Schattner, Mirta, Gómez, Ricardo Martín
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Argentina
Institución:Universidad Nacional de La Plata
Repositorio:SEDICI (UNLP)
Idioma:inglés
OAI Identifier:oai:sedici.unlp.edu.ar:10915/86431
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86431
Access Level:acceso abierto
Palabra clave:Biología
Junin virus
Dendritic Cells
Virology
Arenavirus
Descripción
Sumario:The arenavirus Junin virus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. We characterized the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection with the C#1 strain (attenuated) and even more susceptible to infection with the P (virulent) JUNV strain. However, hpDC elicited different responses in terms of viability, activation, maturation, and cytokine expression after infection with both JUNV strains.

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