Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern comprises several sublineages, with BA.2 and BA.2.12.1 having replaced the previously dominant BA.1 and with BA.4 and BA.5 increasing in prevalence worldwide. We show that the large number of Omicron sublinea...

Full description

Bibliographic Details
Authors: Bowen, John E., Addetia, Amin, Dang, Ha V., Stewart, Cameron, Brown, Jack T., Sharkey, William K., Sprouse, Kaitlin R., Walls, Alexandra C., Mazzitelli, Ignacio Gabriel, Logue, Jennifer K., Franko, Nicholas M., Czudnochowski, Nadine, Powell, Abigail E., Dellota, Exequiel, Ahmed, Kumail, Ansari, Asefa Shariq, Cameroni, Elisabetta, Gori, Andrea, Bandera, Alessandra, Posavad, Christine M., Dan, Jennifer M., Zhang, Zeli, Weiskopf, Daniela, Sette, Alessandro, Crotty, Shane, Iqbal, Najeeha Talat, Corti, Davide, Geffner, Jorge Raúl, Snell, Gyorgy, Grifantini, Renata, Chu, Helen Y., Veesler, David
Format: article
Status:Published version
Publication Date:2022
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/230550
Online Access:http://hdl.handle.net/11336/230550
Access Level:Open access
Keyword:SARS-CoV-2
Antibodies
COVID-19
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
Description
Summary:The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern comprises several sublineages, with BA.2 and BA.2.12.1 having replaced the previously dominant BA.1 and with BA.4 and BA.5 increasing in prevalence worldwide. We show that the large number of Omicron sublineage spike mutations leads to enhanced angiotensin-converting enzyme 2 (ACE2) binding, reduced fusogenicity, and severe dampening of plasma neutralizing activity elicited by infection or seven clinical vaccines relative to the ancestral virus. Administration of a homologous or heterologous booster based on the Wuhan-Hu-1 spike sequence markedly increased neutralizing antibody titers and breadth against BA.1, BA.2, BA.2.12.1, BA.4, and BA.5 across all vaccines evaluated. Our data suggest that although Omicron sublineages evade polyclonal neutralizing antibody responses elicited by primary vaccine series, vaccine boosters may provide sufficient protection against Omicron-induced severe disease.

Similar Items