Neglected Tropical Protozoan Diseases: Drug Repositioning as a Rational Option
Neglected tropical diseases represent a major sanitary problem and a huge economic burden to endemic countries, and are currently expanding to non-endemic countries owing to migration currents. Though long abandoned in the past, recent research on novel therapeutics has already started to show resul...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/40322 |
| Acceso en línea: | http://hdl.handle.net/11336/40322 |
| Access Level: | acceso abierto |
| Palabra clave: | African Trypanosomiasis Chagas Disease Clinical Trials Drug Discovery Drug Repositioning Drug Repurposing Leishmaniasis Neglected Tropical Diseases https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Sumario: | Neglected tropical diseases represent a major sanitary problem and a huge economic burden to endemic countries, and are currently expanding to non-endemic countries owing to migration currents. Though long abandoned in the past, recent research on novel therapeutics has already started to show results. Drug repositioning is one of the prominent, more successful strategies to approach the development of new treatments for these diseases. Here we present an overview on the limitations of the current available medications to treat African trypanosomiasis, Chagas disease and Leishmaniasis, along with a review on drug candidates presently undergoing clinical trials and drug candidates identified through drug repositioning initiatives. |
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