Natural Products and Synthetic Derivatives as Promising Candidates Against Neglected Tropical Diseases

Neglected Tropical Diseases (NTD) are a group of endemic diseases that cause up to one million deaths annually. Leishmaniasis and Chagas Disease are classified as NTD whose current treatments are of limited access. There is an urgent need to develop new agents to combat or alleviate the symptoms of...

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Detalhes bibliográficos
Autores: dos Santos Fuzaro, Ana Flávia, Sousa Ponciano, Carolina, Barros, José C., M. Grazul, Richard, Vieira de Almeida, Mauro, Pereira Ávila, Eloah
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:Brasil
Recursos:Universidade Federal de Mato Grosso do Sul (UFMS)
Repositorio:Orbital - The Electronic Journal of Chemistry (Campo Grande)
Idioma:inglés
OAI Identifier:oai:periodicos.ufms.br:article/16374
Acesso em linha:https://periodicos.ufms.br/index.php/orbital/article/view/16374
Access Level:acceso abierto
Palavra-chave:Chagas Disease
Leishmaniasis
Natural products
Neglected Tropical Diseases – NTD
Trypanosomiasis
Descrição
Resumo:Neglected Tropical Diseases (NTD) are a group of endemic diseases that cause up to one million deaths annually. Leishmaniasis and Chagas Disease are classified as NTD whose current treatments are of limited access. There is an urgent need to develop new agents to combat or alleviate the symptoms of these pathologies. The present work highlights the activities of several natural products and their derivatives which have been tested against the causative parasites of both diseases. The activities of natural products illustrate their potential to assist in the combat against NTD. Research in this area could provide an opportunity to advance medical research and to provide treatments to low- and middle-income countries.