Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis

The spontaneous non-obese diabetic (NOD) mouse model of Sjögren's syndrome provides a valuable tool to study the onset and progression of both the autoimmune response and secretory dysfunction. Our purpose was to analyse the temporal decline of salivary secretion in NOD mice in relation to the...

Descripción completa

Detalles Bibliográficos
Autores: Rosignoli, F., Roca, Valeria Ines, Meiss, R., Leceta, J., Gomariz, Roberto Luis, Perez Leiros, Claudia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2005
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/39392
Acceso en línea:http://hdl.handle.net/11336/39392
Access Level:acceso abierto
Palabra clave:Autoimmune Response
Nitric Oxide Signalling
Nod Mice
Sialadenitis
SjÖGren'S Syndrome
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
id AR_7449f4e89aea4cf9d8eea5cfdca6c7d1
oai_identifier_str oai:ri.conicet.gov.ar:11336/39392
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
title Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
spellingShingle Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
Rosignoli, F.
Autoimmune Response
Nitric Oxide Signalling
Nod Mice
Sialadenitis
SjÖGren'S Syndrome
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
title_full Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
title_fullStr Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
title_full_unstemmed Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
title_sort Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
dc.creator.none.fl_str_mv Rosignoli, F.
Roca, Valeria Ines
Meiss, R.
Leceta, J.
Gomariz, Roberto Luis
Perez Leiros, Claudia
author Rosignoli, F.
author_facet Rosignoli, F.
Roca, Valeria Ines
Meiss, R.
Leceta, J.
Gomariz, Roberto Luis
Perez Leiros, Claudia
author_role author
author2 Roca, Valeria Ines
Meiss, R.
Leceta, J.
Gomariz, Roberto Luis
Perez Leiros, Claudia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Autoimmune Response
Nitric Oxide Signalling
Nod Mice
Sialadenitis
SjÖGren'S Syndrome
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic Autoimmune Response
Nitric Oxide Signalling
Nod Mice
Sialadenitis
SjÖGren'S Syndrome
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description The spontaneous non-obese diabetic (NOD) mouse model of Sjögren's syndrome provides a valuable tool to study the onset and progression of both the autoimmune response and secretory dysfunction. Our purpose was to analyse the temporal decline of salivary secretion in NOD mice in relation to the autoimmune response and alterations in various signalling pathways involved in saliva secretion within each salivary gland. A progressive loss of nitric oxide synthase activity in submandibular and parotid glands started at 12 weeks of age and paralleled the decline in salivary secretion. This defect was associated with a lower response to vasoactive intestinal peptide in salivary flow rate, cAMP and nitric oxide/cGMP production. No signs of mononuclear infiltrates or local cytokine production were detectable in salivary glands in the time period studied (10-16 weeks of age). Our data support a disease model for sialadenitis in NOD mice in which the early stages are characterized by defective neurotransmitter-mediated signalling in major salivary glands that precedes the autoimmune response.
publishDate 2005
dc.date.none.fl_str_mv 2005-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39392
Rosignoli, F.; Roca, Valeria Ines; Meiss, R.; Leceta, J.; Gomariz, Roberto Luis; et al.; Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis; Wiley Blackwell Publishing, Inc; Clinical and Experimental Immunology; 142; 3; 12-2005; 411-418
0009-9104
1365-2249
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39392
identifier_str_mv Rosignoli, F.; Roca, Valeria Ines; Meiss, R.; Leceta, J.; Gomariz, Roberto Luis; et al.; Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis; Wiley Blackwell Publishing, Inc; Clinical and Experimental Immunology; 142; 3; 12-2005; 411-418
0009-9104
1365-2249
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2249.2005.02930.x
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2249.2005.02930.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799196310067216384
spelling Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitisRosignoli, F.Roca, Valeria InesMeiss, R.Leceta, J.Gomariz, Roberto LuisPerez Leiros, ClaudiaAutoimmune ResponseNitric Oxide SignallingNod MiceSialadenitisSjÖGren'S Syndromehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The spontaneous non-obese diabetic (NOD) mouse model of Sjögren's syndrome provides a valuable tool to study the onset and progression of both the autoimmune response and secretory dysfunction. Our purpose was to analyse the temporal decline of salivary secretion in NOD mice in relation to the autoimmune response and alterations in various signalling pathways involved in saliva secretion within each salivary gland. A progressive loss of nitric oxide synthase activity in submandibular and parotid glands started at 12 weeks of age and paralleled the decline in salivary secretion. This defect was associated with a lower response to vasoactive intestinal peptide in salivary flow rate, cAMP and nitric oxide/cGMP production. No signs of mononuclear infiltrates or local cytokine production were detectable in salivary glands in the time period studied (10-16 weeks of age). Our data support a disease model for sialadenitis in NOD mice in which the early stages are characterized by defective neurotransmitter-mediated signalling in major salivary glands that precedes the autoimmune response.Fil: Rosignoli, F.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad Complutense de Madrid; EspañaFil: Roca, Valeria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Meiss, R.. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Leceta, J.. Universidad Complutense de Madrid; EspañaFil: Gomariz, R.P.. Universidad Complutense de Madrid; EspañaFil: Perez Leiros, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaWiley Blackwell Publishing, Inc2005-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39392Rosignoli, F.; Roca, Valeria Ines; Meiss, R.; Leceta, J.; Gomariz, Roberto Luis; et al.; Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis; Wiley Blackwell Publishing, Inc; Clinical and Experimental Immunology; 142; 3; 12-2005; 411-4180009-91041365-2249CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2249.2005.02930.xinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2249.2005.02930.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:22:39Zoai:ri.conicet.gov.ar:11336/39392instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:22:39.897CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
score 15,81155

Similares en LA Referencia