Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
The spontaneous non-obese diabetic (NOD) mouse model of Sjögren's syndrome provides a valuable tool to study the onset and progression of both the autoimmune response and secretory dysfunction. Our purpose was to analyse the temporal decline of salivary secretion in NOD mice in relation to the...
| Autores: | , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2005 |
| País: | Argentina |
| Recursos: | Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
| Repositório: | Biblioteca Digital (UBA-FCEN) |
| Idioma: | inglês |
| OAI Identifier: | paperaa:paper_00099104_v142_n3_p411_Rosignoli |
| Acesso em linha: | http://hdl.handle.net/20.500.12110/paper_00099104_v142_n3_p411_Rosignoli |
| Access Level: | Acceso aberto |
| Palavra-chave: | Autoimmune response Nitric oxide signalling NOD mice Sialadenitis Sjögren's syndrome cyclic AMP cyclic GMP neurotransmitter nitric oxide nitric oxide synthase vasoactive intestinal polypeptide animal experiment animal model animal tissue article autoimmunity cell infiltration cytokine production enzyme activity female immune response mononuclear cell mouse mouse strain nonhuman parotid gland priority journal salivary gland salivation sialoadenitis signal transduction Sjoegren syndrome submandibular gland Animals Autoantibodies Autoimmunity Cyclic GMP Cytokines Diabetes Mellitus, Type 1 Disease Models, Animal Female Mice Mice, Inbred BALB C Mice, Inbred NOD Nitric Oxide Synthase Parotid Gland Salivary Glands Signal Transduction Submandibular Gland Vasoactive Intestinal Peptide |
| Resumo: | The spontaneous non-obese diabetic (NOD) mouse model of Sjögren's syndrome provides a valuable tool to study the onset and progression of both the autoimmune response and secretory dysfunction. Our purpose was to analyse the temporal decline of salivary secretion in NOD mice in relation to the autoimmune response and alterations in various signalling pathways involved in saliva secretion within each salivary gland. A progressive loss of nitric oxide synthase activity in submandibular and parotid glands started at 12 weeks of age and paralleled the decline in salivary secretion. This defect was associated with a lower response to vasoactive intestinal peptide in salivary flow rate, cAMP and nitric oxide/cGMP production. No signs of mononuclear infiltrates or local cytokine production were detectable in salivary glands in the time period studied (10-16 weeks of age). Our data support a disease model for sialadenitis in NOD mice in which the early stages are characterized by defective neurotransmitter-mediated signalling in major salivary glands that precedes the autoimmune response. © 2005 British Society for Immunology. |
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