C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria

Ferroptosis is an oxidative and iron-dependent form of regulated cell death (RCD) recently described in eukaryotic organisms like animals, plants, and parasites. Here, we report that a similar process takes place in the photosynthetic prokaryote Synechocystis sp. PCC 6803 in response to heat stress....

Descripción completa

Detalles Bibliográficos
Autores: Aguilera, Anabella, Berdun, Federico Juan, Bartoli, Carlos Guillermo, Steelheart Molina, Maria Charlotte, Alegre, Matías, Bayir, Hülya, Tyurina, Yulia Y., Kagan, Valerian E., Salerno, Graciela Lidia, Pagnussat, Gabriela Carolina, Martin, María Victoria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/149883
Acceso en línea:http://hdl.handle.net/11336/149883
Access Level:acceso abierto
Palabra clave:FERROPTOSIS
CYANOBACTERIA
CELL DEATH
ASCORBIC ACID
GLUTATHIONE
IRON
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
id AR_6bfb58ea65ed03c12295aedfd52ef59a
oai_identifier_str oai:ri.conicet.gov.ar:11336/149883
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria
title C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria
spellingShingle C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria
Aguilera, Anabella
FERROPTOSIS
CYANOBACTERIA
CELL DEATH
ASCORBIC ACID
GLUTATHIONE
IRON
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria
title_full C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria
title_fullStr C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria
title_full_unstemmed C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria
title_sort C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria
dc.creator.none.fl_str_mv Aguilera, Anabella
Berdun, Federico Juan
Bartoli, Carlos Guillermo
Steelheart Molina, Maria Charlotte
Alegre, Matías
Bayir, Hülya
Tyurina, Yulia Y.
Kagan, Valerian E.
Salerno, Graciela Lidia
Pagnussat, Gabriela Carolina
Martin, María Victoria
author Aguilera, Anabella
author_facet Aguilera, Anabella
Berdun, Federico Juan
Bartoli, Carlos Guillermo
Steelheart Molina, Maria Charlotte
Alegre, Matías
Bayir, Hülya
Tyurina, Yulia Y.
Kagan, Valerian E.
Salerno, Graciela Lidia
Pagnussat, Gabriela Carolina
Martin, María Victoria
author_role author
author2 Berdun, Federico Juan
Bartoli, Carlos Guillermo
Steelheart Molina, Maria Charlotte
Alegre, Matías
Bayir, Hülya
Tyurina, Yulia Y.
Kagan, Valerian E.
Salerno, Graciela Lidia
Pagnussat, Gabriela Carolina
Martin, María Victoria
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv FERROPTOSIS
CYANOBACTERIA
CELL DEATH
ASCORBIC ACID
GLUTATHIONE
IRON
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic FERROPTOSIS
CYANOBACTERIA
CELL DEATH
ASCORBIC ACID
GLUTATHIONE
IRON
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description Ferroptosis is an oxidative and iron-dependent form of regulated cell death (RCD) recently described in eukaryotic organisms like animals, plants, and parasites. Here, we report that a similar process takes place in the photosynthetic prokaryote Synechocystis sp. PCC 6803 in response to heat stress. After a heat shock, Synechocystis sp. PCC 6803 cells undergo a cell death pathway that can be suppressed by the canonical ferroptosis inhibitors, CPX, vitamin E, Fer-1, liproxstatin-1, glutathione (GSH), or ascorbic acid (AsA). Moreover, as described for eukaryotic ferroptosis, this pathway is characterized by an early depletion of the antioxidants GSH and AsA, and by lipid peroxidation. These results indicate that all of the hallmarks described for eukaryotic ferroptosis are conserved in photosynthetic prokaryotes and suggest that ferroptosis might be an ancient cell death program.
publishDate 2021
dc.date.none.fl_str_mv 2021-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/149883
Aguilera, Anabella; Berdun, Federico Juan; Bartoli, Carlos Guillermo; Steelheart Molina, Maria Charlotte; Alegre, Matías; et al.; C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria; Rockefeller University Press; Journal of Cell Biology; 221; 2; 11-2021
0021-9525
CONICET Digital
CONICET
url http://hdl.handle.net/11336/149883
identifier_str_mv Aguilera, Anabella; Berdun, Federico Juan; Bartoli, Carlos Guillermo; Steelheart Molina, Maria Charlotte; Alegre, Matías; et al.; C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria; Rockefeller University Press; Journal of Cell Biology; 221; 2; 11-2021
0021-9525
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://rupress.org/jcb/article/221/2/e201911005/212878/C-ferroptosis-is-an-iron-dependent-form-of
info:eu-repo/semantics/altIdentifier/doi/10.1083/jcb.201911005
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Rockefeller University Press
publisher.none.fl_str_mv Rockefeller University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799194807273259008
spelling C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteriaAguilera, AnabellaBerdun, Federico JuanBartoli, Carlos GuillermoSteelheart Molina, Maria CharlotteAlegre, MatíasBayir, HülyaTyurina, Yulia Y.Kagan, Valerian E.Salerno, Graciela LidiaPagnussat, Gabriela CarolinaMartin, María VictoriaFERROPTOSISCYANOBACTERIACELL DEATHASCORBIC ACIDGLUTATHIONEIRONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Ferroptosis is an oxidative and iron-dependent form of regulated cell death (RCD) recently described in eukaryotic organisms like animals, plants, and parasites. Here, we report that a similar process takes place in the photosynthetic prokaryote Synechocystis sp. PCC 6803 in response to heat stress. After a heat shock, Synechocystis sp. PCC 6803 cells undergo a cell death pathway that can be suppressed by the canonical ferroptosis inhibitors, CPX, vitamin E, Fer-1, liproxstatin-1, glutathione (GSH), or ascorbic acid (AsA). Moreover, as described for eukaryotic ferroptosis, this pathway is characterized by an early depletion of the antioxidants GSH and AsA, and by lipid peroxidation. These results indicate that all of the hallmarks described for eukaryotic ferroptosis are conserved in photosynthetic prokaryotes and suggest that ferroptosis might be an ancient cell death program.Fil: Aguilera, Anabella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Biodiversidad y Biotecnología; ArgentinaFil: Berdun, Federico Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Biodiversidad y Biotecnología; ArgentinaFil: Bartoli, Carlos Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Fisiología Vegetal. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Instituto de Fisiología Vegetal; ArgentinaFil: Steelheart Molina, Maria Charlotte. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Fisiología Vegetal. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Instituto de Fisiología Vegetal; ArgentinaFil: Alegre, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Fisiología Vegetal. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Instituto de Fisiología Vegetal; ArgentinaFil: Bayir, Hülya. University of Pittsburgh; Estados UnidosFil: Tyurina, Yulia Y.. University of Pittsburgh; Estados UnidosFil: Kagan, Valerian E.. University of Pittsburgh; Estados UnidosFil: Salerno, Graciela Lidia. Fundación para Investigaciones Biológicas Aplicadas; ArgentinaFil: Pagnussat, Gabriela Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; ArgentinaFil: Martin, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Biodiversidad y Biotecnología; ArgentinaRockefeller University Press2021-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/149883Aguilera, Anabella; Berdun, Federico Juan; Bartoli, Carlos Guillermo; Steelheart Molina, Maria Charlotte; Alegre, Matías; et al.; C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria; Rockefeller University Press; Journal of Cell Biology; 221; 2; 11-20210021-9525CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://rupress.org/jcb/article/221/2/e201911005/212878/C-ferroptosis-is-an-iron-dependent-form-ofinfo:eu-repo/semantics/altIdentifier/doi/10.1083/jcb.201911005info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:36:51Zoai:ri.conicet.gov.ar:11336/149883instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:36:51.352CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
score 15.812429

Similares en LA Referencia