Determination of loratadine and pseudoephedrine sulfate in pharmaceuticals based on non-linear second-order spectrophotometric data generated by a pH-gradient flow injection technique and artificial neural networks
Loratadine (LOR) and pseudoephedrine sulfate (PES) were determined in pharmaceutical samples by using non-linear second-order data generated by a pH-gradient flow injection analysis (FIA) system with diode-array detection. Determination of both analytes was performed on the basis of differences betw...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2007 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/114395 |
| Acceso en línea: | http://hdl.handle.net/11336/114395 |
| Access Level: | acceso abierto |
| Palabra clave: | ARTIFICIAL NEURAL NETWORKS LORATADINE PHARMACEUTICAL PSEUDOEPHEDRINE SECOND-ORDER ADVANTAGE https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Sumario: | Loratadine (LOR) and pseudoephedrine sulfate (PES) were determined in pharmaceutical samples by using non-linear second-order data generated by a pH-gradient flow injection analysis (FIA) system with diode-array detection. Determination of both analytes was performed on the basis of differences between the acid-base and spectral features of each drug species. Non-linearities were detected by using both qualitative and quantitative tools. As a consequence of the non-linearity, a recently reported algorithm, artificial neural networks followed by residual bilinearization (ANN/RBL), was shown to furnish more satisfactory results. Recoveries of 99.7% (LOR) and 95.6% (PES) were obtained when analyzing a validation set containing unexpected components (the usual excipients found in pharmaceutical preparations). The average value obtained by implementation of the method on four replicates was compared with that obtained by a reference method based on HPLC (difference not significant; p > 0.05). |
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