Rapid and efficient synthesis of five- to eight-membered cyclic aminals under ultrasound irradiation

A simple, efficient, and green procedure has been developed for the synthesis of cyclic aminals from alkylenediamines and aqueous formaldehyde under ultrasound irradiation. Applying this methodology a series of five-to eight-membered 1,3-dibenzyl substituted aminals were synthesized in excellent yie...

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Detalhes bibliográficos
Autores: Ramírez, María Amelia, Ortiz, Gisela, Levin, Gustavo Javier, Mac Cormack, Walter Patricio, Blanco, María de Las Mercedes, Perillo, Isabel Amalia, Salerno, Alejandra
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2014
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositório:CONICET Digital (CONICET)
Idioma:inglês
OAI Identifier:oai:ri.conicet.gov.ar:11336/30604
Acesso em linha:http://hdl.handle.net/11336/30604
Access Level:Acceso aberto
Palavra-chave:Cyclic Aminals
Alkylenediamines
Ultrasonic Assisted Synthesis
Green Chemistry
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
Descrição
Resumo:A simple, efficient, and green procedure has been developed for the synthesis of cyclic aminals from alkylenediamines and aqueous formaldehyde under ultrasound irradiation. Applying this methodology a series of five-to eight-membered 1,3-dibenzyl substituted aminals were synthesized in excellent yields after short reaction times. Results were compared to thermal conventional method. All novel compounds were identified and characterized by 1H and 13C NMR spectra.