Prognostic value of ATN Alzheimer biomarkers: 60-month follow-up results from the Argentine Alzheimer's Disease Neuroimaging Initiative

Purpose: To describe results of the Amyloid, Tau, Neurodegeneration (ATN) research framework classification in the Argentine-Alzheimer's Disease Neuroimaging Initiative (arg-ADNI) cohort. Methods: Twenty-three patients with mild cognitive impairment (MCI), 12 dementia of Alzheimer's type (...

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Detalles Bibliográficos
Autores: Allegri, Ricardo Francisco, Chrem Mendez, Patricio Alexis, Calandri, Ismael, Cohen, Gabriela, Martin, María Eugenia, Russo, María Julieta, Crivelli, Lucía, Pertierra, Lucia, Tapajóz, Fernanda, Clarens, María Florencia, Campos Tapia, Jorge Andrés, Nahas, Federico Exequiel, Díaz Vázquez, María Silvia Johanna, Surace, Ezequiel Ignacio, Sevlever, Gustavo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/168792
Acceso en línea:http://hdl.handle.net/11336/168792
Access Level:acceso abierto
Palabra clave:ALZHEIMER'S DISEASE
AMYLOID
BIOMARKERS
CLASSIFICATION
NEURODEGENERATION
TAU
https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
Descripción
Sumario:Purpose: To describe results of the Amyloid, Tau, Neurodegeneration (ATN) research framework classification in the Argentine-Alzheimer's Disease Neuroimaging Initiative (arg-ADNI) cohort. Methods: Twenty-three patients with mild cognitive impairment (MCI), 12 dementia of Alzheimer's type (DAT), and 14 normal controls were studied following the ADNI2 protocol. Patients were categorized according to presence or absence of the biomarkers for amyloid beta (Aβ; A: amyloid positron emission tomography [PET] scan or cerebrospinal fluid [CSF] Aβ42), tau (T: CSF phosphorylated-tau), and neurodegeneration (N: CSF total-tau, fluorodeoxyglucose [FDG]-PET scan, or structural magnetic resonance imaging [MRI] scan). Results: A+T+N+ biomarker profile was identified at baseline in 91% of mild dementia patients, 20% of early MCI patients, 46% of late MCI patients, and 14% of control subjects. Suspected non-AD pathophysiology (SNAP, A-T-N+) was found in 8% of mild dementia, 20% of early MCI, 15% of late MCI, and 7% of control subjects. Conversion rates to dementia after 5-year follow-up were 85% in A+T+N+ MCI patients and 50% in A-T-N+ patients. Conclusions: We present initial 5-year follow-up results of a regional ADNI based on AD biomarkers and the ATN classification.

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