A fast fluorimetric flow injection method to determine ibuprofen
The native fluorescence of ibuprofen was enhanced when a host-guest complex of the analyte with b cyclodextrin (b-CD) was formed. So, based on this fact, a flow injection method to determine ibuprofen in different pharmaceutical preparations with fluorescence detection (lem 287 nm, lexc 223 nm) was...
| Autores: | , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2006 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/119419 |
| Acceso en línea: | http://hdl.handle.net/11336/119419 |
| Access Level: | acceso abierto |
| Palabra clave: | IBUPROFEN FIA SPECTROFLUORIMETRIC PHARMACEUTICAL PREPARATION https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Sumario: | The native fluorescence of ibuprofen was enhanced when a host-guest complex of the analyte with b cyclodextrin (b-CD) was formed. So, based on this fact, a flow injection method to determine ibuprofen in different pharmaceutical preparations with fluorescence detection (lem 287 nm, lexc 223 nm) was developed. The calibration curve was linear over the range 6.00 – 60.0 mg L-1 of ibuprofen and the detection limit (LOD) for S/N=3 was 4.5 mg L-1. The relative standard deviation was 1.2% and the sample throughput 240 h-1. The method was validated by comparing the proposed and the official method to commercial preparation samples. |
|---|