Low level laser therapy (LLLT) modulates ovarian function in mature female mice

It is known that LLLT has beneficial effects on several pathological conditions including wound healing,pain and inflammation. LLLT modulates biological processes, including cell proliferation, apoptosis andangiogenesis. In the present study, we examined the effect of local application of LLLT on fo...

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Bibliographic Details
Authors: Oubiña, Gonzalo, Pascuali, Natalia Marisa, Scotti, Leopoldina, Di Pietro, Mariana, la Spina, Florenza Antonella, Buffone, Mariano Gabriel, Higuera, Javier, Abramovich, Dalhia Nurit, Parborell, Maria Fernanda Agustina
Format: article
Status:Published version
Publication Date:2019
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/85373
Online Access:http://hdl.handle.net/11336/85373
Access Level:Open access
Keyword:OVARY
LOW LEVEL LASER THERAPY
FOLLICULOGENESIS
APOPTOSIS
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
Description
Summary:It is known that LLLT has beneficial effects on several pathological conditions including wound healing,pain and inflammation. LLLT modulates biological processes, including cell proliferation, apoptosis andangiogenesis. In the present study, we examined the effect of local application of LLLT on follicular dynamics,ovarian reserve, AMH expression, progesterone levels, apoptosis, angiogenesis, and reproductiveoutcome in adult mice. LLLT (200 J/cm2) increased the percentage of primary and preantral follicles,whilst decreasing the percentage of corpora lutea compared to control ovaries. LLLT-treated ovaries didnot exhibit any changes regarding the number of primordial follicles.We observed a higher percentage ofAMH-positive follicles (in early stages of development) in LLLT-treated ovaries compared to controlovaries. LLLT reduced the P4 concentration and the apoptosis in early antral follicles compared to controlones. LLLT caused a reduction in the endothelial cell area and an increase in the periendothelial cell areain the ovary. Additionally, LLLT was able to improve oocyte quality. Our findings suggest that localapplication of LLLT modulates follicular dynamics by regulating apoptosis and the vascular stability inmouse ovary. In conclusion, these data indicate that LLLT might become a novel and useful tool in thetreatment of several pathologies, including female reproductive disorders.

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