Development of improved pertussis vaccine

Rates of infection with Bordetella pertussis, the gram-negative bacterium that causes the respiratory disease called whooping cough or pertussis, have not abated and 16 million cases with almost 200,000 deaths are estimated by the WHO to have occurred worldwide in 2008. Despite relatively high vacci...

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Detalles Bibliográficos
Autores: Rumbo, Martín, Hozbor, Daniela Flavia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/33157
Acceso en línea:http://hdl.handle.net/11336/33157
Access Level:acceso abierto
Palabra clave:Whooping Cough
Pertussis
Bordetella Pertussis
Bordetella Parapertussis
Vaccines
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
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spelling Development of improved pertussis vaccineRumbo, MartínHozbor, Daniela FlaviaWhooping CoughPertussisBordetella PertussisBordetella ParapertussisVaccineshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Rates of infection with Bordetella pertussis, the gram-negative bacterium that causes the respiratory disease called whooping cough or pertussis, have not abated and 16 million cases with almost 200,000 deaths are estimated by the WHO to have occurred worldwide in 2008. Despite relatively high vaccination rates, the disease has come back in recent years to afflict people in numbers not seen since the pre-vaccine days. Indeed, pertussis is now recognized as a frequent infection not only in newborn and infants but also in adults. The disease symptoms also can be induced by the non-vaccine-preventable infection with the close species B. parapertussis for which an increasing number of cases have been reported. The epidemiologic situation and current knowledge of the limitations of pertussis vaccine point out the need to design improved vaccines. Several alternative approaches and their challenges are summarized.Fil: Rumbo, Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; ArgentinaFil: Hozbor, Daniela Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; ArgentinaLandes Bioscience2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/33157Rumbo, Martín; Hozbor, Daniela Flavia; Development of improved pertussis vaccine; Landes Bioscience; Human Vaccines; 10; 8; 8-2014; 1-41554-8619CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.4161/hv.29253info:eu-repo/semantics/altIdentifier/doi/10.4161/hv.29253info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:02:20Zoai:ri.conicet.gov.ar:11336/33157instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:02:21.025CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Development of improved pertussis vaccine
title Development of improved pertussis vaccine
spellingShingle Development of improved pertussis vaccine
Rumbo, Martín
Whooping Cough
Pertussis
Bordetella Pertussis
Bordetella Parapertussis
Vaccines
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Development of improved pertussis vaccine
title_full Development of improved pertussis vaccine
title_fullStr Development of improved pertussis vaccine
title_full_unstemmed Development of improved pertussis vaccine
title_sort Development of improved pertussis vaccine
dc.creator.none.fl_str_mv Rumbo, Martín
Hozbor, Daniela Flavia
author Rumbo, Martín
author_facet Rumbo, Martín
Hozbor, Daniela Flavia
author_role author
author2 Hozbor, Daniela Flavia
author2_role author
dc.subject.none.fl_str_mv Whooping Cough
Pertussis
Bordetella Pertussis
Bordetella Parapertussis
Vaccines
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic Whooping Cough
Pertussis
Bordetella Pertussis
Bordetella Parapertussis
Vaccines
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description Rates of infection with Bordetella pertussis, the gram-negative bacterium that causes the respiratory disease called whooping cough or pertussis, have not abated and 16 million cases with almost 200,000 deaths are estimated by the WHO to have occurred worldwide in 2008. Despite relatively high vaccination rates, the disease has come back in recent years to afflict people in numbers not seen since the pre-vaccine days. Indeed, pertussis is now recognized as a frequent infection not only in newborn and infants but also in adults. The disease symptoms also can be induced by the non-vaccine-preventable infection with the close species B. parapertussis for which an increasing number of cases have been reported. The epidemiologic situation and current knowledge of the limitations of pertussis vaccine point out the need to design improved vaccines. Several alternative approaches and their challenges are summarized.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/33157
Rumbo, Martín; Hozbor, Daniela Flavia; Development of improved pertussis vaccine; Landes Bioscience; Human Vaccines; 10; 8; 8-2014; 1-4
1554-8619
CONICET Digital
CONICET
url http://hdl.handle.net/11336/33157
identifier_str_mv Rumbo, Martín; Hozbor, Daniela Flavia; Development of improved pertussis vaccine; Landes Bioscience; Human Vaccines; 10; 8; 8-2014; 1-4
1554-8619
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.4161/hv.29253
info:eu-repo/semantics/altIdentifier/doi/10.4161/hv.29253
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Landes Bioscience
publisher.none.fl_str_mv Landes Bioscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15,812429

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